Ghosh A K, Sharma A, Talukder G
Department of Botany, University of Calcutta, India.
Cytobios. 1992;71(285):85-91.
The ability of Sumicidin, a synthetic pyrethroid, to induce cytotoxicity in Swiss albino mice was evaluated before completion of the first cell division following oral exposure. Mice were administered orally different concentrations (32.50, 75 and 150 mg/kg body wt) of Sumicidin in a single dose. Mitotic index and chromosomal aberrations were screened after 6, 12 and 24 h following exposure. The frequency of dividing cells decreased significantly, indicating mitostatic action. The frequency of chromosomal aberrations was directly related to the concentrations used and the duration after exposure, and was significant at all concentrations. The highest frequency of aberrations was observed 24 h after exposure.
在口服暴露后第一次细胞分裂完成之前，评估了合成拟除虫菊酯速灭菊酯在瑞士白化小鼠中诱导细胞毒性的能力。小鼠单次口服不同浓度（32.50、75和150毫克/千克体重）的速灭菊酯。在暴露后6、12和24小时筛选有丝分裂指数和染色体畸变。分裂细胞的频率显著降低，表明有丝分裂抑制作用。染色体畸变的频率与所用浓度和暴露后的持续时间直接相关，并且在所有浓度下都很显著。在暴露后24小时观察到最高的畸变频率。
