Witzel J G, Prescher A, Weisser H
Department of Anatomy, Medical Faculty, Technical University of Aachen, FRG.
Chemotherapy. 1992;38(4):251-60. doi: 10.1159/000239008.
In previous studies radiation-induced osteosarcoma transplanted onto nude rats has been shown to have an extraordinary similarity to human osteosarcoma. In this report the effects of a standard chemotherapeutic regimen on this experimental bone tumor are described. Examination of the histology and of the water content of the tumor confirmed that a high-dose cyclophosphamide monotherapy can cause severe necrosis in the tumor and its seeded lung metastases. A significant decrease in tumor volume of 50% (p < or = 0.01) was provoked and increased the mean survival rate of the treated rats (untreated rats: mean = 39.3 days) significantly to 53.6 days after transplantation of tumor fragments (p < or = 0.01).
在先前的研究中，已表明移植到裸鼠身上的辐射诱导骨肉瘤与人类骨肉瘤具有非同寻常的相似性。在本报告中，描述了一种标准化疗方案对这种实验性骨肿瘤的影响。对肿瘤的组织学和含水量进行检查证实，高剂量环磷酰胺单一疗法可导致肿瘤及其肺转移灶发生严重坏死。肿瘤体积显著减少了50%（p≤0.01），并使经治疗大鼠的平均存活率（未治疗大鼠：平均为39.3天）在移植肿瘤碎片后显著提高至53.6天（p≤0.01）。
