Witzel J G, Prescher A
Institute for Anatomy I, Technical University of Aachen, FRG.
Invasion Metastasis. 1991;11(2):110-5.
In this report we describe an experimental osteogenic sarcoma that had been radiation-induced on Sprague-Dawleys by Delbrück in 1980. We transplanted it to 120 athymic nude rats achieving take rates of 100%. The tumor doubling time was 10.5 days. The osteosarcoma on athymic rats thus proliferated extraordinarily well compared to other known models. Pulmonary metastases were demonstrated in 100% of the examined animals. Pathological examinations revealed morphological similarities to human osteosarcoma and no signs of anaplasia.
在本报告中，我们描述了1980年由德尔布吕克在斯普拉格-道利大鼠身上辐射诱导产生的一种实验性骨肉瘤。我们将其移植到120只无胸腺裸鼠身上，成功率达100%。肿瘤倍增时间为10.5天。因此，与其他已知模型相比，无胸腺大鼠身上的骨肉瘤增殖得非常好。在100%的受试动物中都发现了肺转移。病理检查显示其形态与人类骨肉瘤相似，且无退行发育迹象。
