甲型肝炎中的纤维蛋白环肉芽肿。

Fibrin ring granulomas in hepatitis A.

作者信息

Ruel M, Sevestre H, Henry-Biabaud E, Courouce A M, Capron J P, Erlinger S

机构信息

Médecine interne et gastro-entérologie, Hôpital de Senlis, Senlis, France.

出版信息

Dig Dis Sci. 1992 Dec;37(12):1915-7. doi: 10.1007/BF01308088.

DOI:10.1007/BF01308088

PMID:1473440

Abstract

Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypersensitivity to allopurinol. We describe a case of serologically confirmed viral hepatitis A with this lesion in the liver biopsy. A false positive anti-hepatitis A virus IgM result has been excluded. This is, to our knowledge, the second reported case of type A hepatitis with hepatic fibrin ring granulomas. It confirms that hepatitis A should be included in the differential diagnosis of this lesion.

摘要

纤维蛋白环肉芽肿的特征是围绕中央脂肪空泡的纤维蛋白环。它已在Q热患者的肝脏和骨髓中发现，偶尔也见于内脏利什曼病、巨细胞病毒、爱泼斯坦-巴尔病毒、表皮葡萄球菌感染、霍奇金淋巴瘤以及对别嘌醇过敏的患者。我们描述了一例经血清学确诊为甲型病毒性肝炎且肝活检发现此病变的病例。已排除甲型肝炎病毒IgM假阳性结果。据我们所知，这是第二例报告的伴有肝纤维蛋白环肉芽肿的甲型肝炎病例。它证实甲型肝炎应纳入此病变的鉴别诊断。