Nagai Yasuo, Tsugane Mamiko, Oka Jun-Ichiro, Kimura Hideo
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
FASEB J. 2004 Mar;18(3):557-9. doi: 10.1096/fj.03-1052fje. Epub 2004 Jan 20.
Hydrogen sulfide (H2S) modifies hippocampal long-term potentiation (LTP) and functions as a neuromodulator. Here, we show that H2S increases intracellular Ca2+ and induces Ca2+ waves in primary cultures of astrocytes as well as hippocampal slices. H2S increases the influx of Ca2+ and to a lesser extent causes the release from intracellular Ca2+ stores. Ca2+ waves induced by neuronal excitation as well as responses to exogenously applied H2S are potently blocked by La3+ and Gd3+, inhibitors of Ca2+ channels. These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes.
硫化氢（H₂S）可调节海马体的长时程增强（LTP），并作为一种神经调节剂发挥作用。在此，我们表明H₂S可增加原代培养的星形胶质细胞以及海马体切片中的细胞内Ca²⁺ 并诱导Ca²⁺ 波。H₂S增加Ca²⁺ 的内流，并在较小程度上导致细胞内Ca²⁺ 储存的释放。由神经元兴奋诱导的Ca²⁺ 波以及对外源性应用H₂S的反应均被Ca²⁺ 通道抑制剂La³⁺ 和Gd³⁺ 有效阻断。这些观察结果表明，H₂S诱导的Ca²⁺ 波可传播至相邻的星形胶质细胞。
