Lacki J, Markowska J, Wiktorowicz K
Cell. Immunol. Lab., University School of Medicine, Poznan.
Eur J Gynaecol Oncol. 1992;13(6):475-9.
Phenotype of lymphocytes was estimated in 16 peritoneal fluids obtained from 9 ovarian cancer patients. Peritoneal fluids contained predominantly T cells (more than 80%) while B cell content was relatively low. Approximately 50% lymphocytes carried T-helper cell marker (CD4). Percentage of T-cytotoxic/suppressor cells (CD8+ cells) differed between patients with progression and those showing no tumor progression (19.0 +/- 7.5 vs 32.7 +/- 18.5). CD4/CD8 ratio was higher in the group of patients with progression than in the group with no progression of the tumor (3.4 +/- 2.1 and 2.0 +/- 1.5). Chemotherapy did not affect the parameters. Estimation of CD8 and CD4/CD8 ratio in peritoneal fluid cells could be helpful in monitoring of disease progression.
对9例卵巢癌患者的16份腹腔积液中的淋巴细胞表型进行了评估。腹腔积液中主要为T细胞（超过80%），而B细胞含量相对较低。约50%的淋巴细胞携带辅助性T细胞标志物（CD4）。有病情进展的患者与无肿瘤进展的患者相比，细胞毒性/抑制性T细胞（CD8+细胞）的百分比存在差异（分别为19.0±7.5和32.7±18.5）。肿瘤进展组患者的CD4/CD8比值高于无进展组（分别为3.4±2.1和2.0±1.5）。化疗对这些参数没有影响。评估腹腔积液细胞中的CD8及CD4/CD8比值可能有助于监测疾病进展。
