Kojima T, Isozaki-Fukuda Y, Takedatsu M, Ono A, Hirata Y, Kobayashi Y
Department of Paediatrics, Kansai Medical University, Osaka, Japan.
Eur J Pediatr. 1992 Dec;151(12):913-5. doi: 10.1007/BF01954129.
We attempted to determine the plasma endothelin-1-like immunoreactivity (ET-1) levels and to evaluate its physiological significance in 29 neonates: 5 with respiratory distress syndrome (RDS), 3 with transient tachypnoea of the newborn (TTN), 4 with neonatal asphyxia, 5 with bronchopulmonary dysplasia (BPD) following RDS, 7 healthy preterm infants and 5 healthy full-term infants. Plasma ET-1 levels in infants with RDS were significantly higher than those in healthy full-term infants through the 1st week of life. Plasma ET-1 levels in infants with neonatal asphyxia were high on the first 2 days of life and then gradually decreased to those of healthy full-term infants. Plasma levels in infants with TTN were the same as those in healthy full-term infants. Plasma ET-1 levels in infants with BPD were high when compared with those in healthy preterm infants during the first 2 months of life. This study showed that plasma levels were markedly elevated for a long time in the infants with respiratory distress. We speculate that plasma ET-1 may be a specific marker for pulmonary endothelium injury in infants with respiratory distress.
我们试图测定29例新生儿的血浆内皮素-1样免疫反应性（ET-1）水平，并评估其生理意义：5例患有呼吸窘迫综合征（RDS）、3例患有新生儿短暂性呼吸急促（TTN）、4例患有新生儿窒息、5例患有RDS后的支气管肺发育不良（BPD）、7例健康早产儿和5例健康足月儿。在出生后的第一周内，患有RDS的婴儿血浆ET-1水平显著高于健康足月儿。患有新生儿窒息的婴儿在出生后的头两天血浆ET-1水平较高，然后逐渐降至健康足月儿的水平。患有TTN的婴儿血浆水平与健康足月儿相同。在出生后的头两个月内，患有BPD的婴儿血浆ET-1水平高于健康早产儿。这项研究表明，患有呼吸窘迫的婴儿血浆水平在很长一段时间内显著升高。我们推测，血浆ET-1可能是患有呼吸窘迫的婴儿肺内皮损伤的特异性标志物。
