欧洲儿科内分泌学会/劳森威尔金斯儿科内分泌学会关于儿童和青少年糖尿病酮症酸中毒的共识声明
ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents.
作者信息
Dunger D B, Sperling M A, Acerini C L, Bohn D J, Daneman D, Danne T P A, Glaser N S, Hanas R, Hintz R L, Levitsky L L, Savage M O, Tasker R C, Wolfsdorf J I
机构信息
University of Cambridge, Department of Paediatrics, Addenbrooke's Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK.
出版信息
Arch Dis Child. 2004 Feb;89(2):188-94. doi: 10.1136/adc.2003.044875.
Abstract
Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Mortality is predominantly related to the occurrence of cerebral oedema; only a minority of deaths in DKA are attributed to other causes. Cerebral oedema occurs in about 0.3-1% of all episodes of DKA, and its aetiology, pathophysiology, and ideal method of treatment are poorly understood. There is debate as to whether physicians treating DKA can prevent or predict the occurrence of cerebral oedema, and the appropriate site(s) for children with DKA to be managed. There is agreement that prevention of DKA and reduction of its incidence should be a goal in managing children with diabetes.
摘要
糖尿病酮症酸中毒（DKA）是1型糖尿病（TIDM）患儿发病和死亡的主要原因。死亡主要与脑水肿的发生有关；DKA中只有少数死亡归因于其他原因。脑水肿发生在所有DKA发作中的约0.3%-1%，其病因、病理生理学和理想的治疗方法尚不清楚。对于治疗DKA的医生是否能够预防或预测脑水肿的发生，以及DKA患儿的合适管理地点存在争议。人们一致认为，预防DKA并降低其发病率应是糖尿病患儿管理的一个目标。
相似文献
1
ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents.欧洲儿科内分泌学会/劳森威尔金斯儿科内分泌学会关于儿童和青少年糖尿病酮症酸中毒的共识声明
Arch Dis Child. 2004 Feb;89(2):188-94. doi: 10.1136/adc.2003.044875.
2
The International Society of Pediatric and Adolescent Diabetes guidelines for management of diabetic ketoacidosis: Do the guidelines need to be modified?国际儿科青少年糖尿病学会糖尿病酮症酸中毒管理指南：这些指南是否需要修改？
Pediatr Diabetes. 2014 Jun;15(4):277-86. doi: 10.1111/pedi.12154.
3
Diabetic ketoacidosis and cerebral oedema in Sweden--a 2-year paediatric population study.瑞典的糖尿病酮症酸中毒和脑水肿——一项为期两年的儿科人群研究。
Diabet Med. 2007 Oct;24(10):1080-5. doi: 10.1111/j.1464-5491.2007.02200.x. Epub 2007 Aug 2.
4
Management of diabetic ketoacidosis in children and adolescents.儿童和青少年糖尿病酮症酸中毒的管理
Pediatr Rev. 2008 Dec;29(12):431-5; quiz 436. doi: 10.1542/pir.29-12-431.
5
The lethargic diabetic: cerebral edema in pediatric patients in diabetic ketoacidosis.嗜睡的糖尿病患者：糖尿病酮症酸中毒患儿的脑水肿
Air Med J. 2015 Mar-Apr;34(2):109-12. doi: 10.1016/j.amj.2014.10.009.
6
Management of diabetic ketoacidosis in children and adolescents.儿童和青少年糖尿病酮症酸中毒的管理
Paediatr Drugs. 2008;10(4):209-15. doi: 10.2165/00148581-200810040-00002.
7
The risk and outcome of cerebral oedema developing during diabetic ketoacidosis.糖尿病酮症酸中毒期间发生脑水肿的风险及后果。
Arch Dis Child. 2001 Jul;85(1):16-22. doi: 10.1136/adc.85.1.16.
8
Treatment of diabetic ketoacidosis in children and adolescents.儿童和青少年糖尿病酮症酸中毒的治疗。
Acta Biomed. 2003 Aug;74(2):59-68.
9
Cerebral oedema in childhood diabetic ketoacidosis: is treatment a factor?儿童糖尿病酮症酸中毒中的脑水肿：治疗是一个因素吗？
Emerg Med J. 2004 Mar;21(2):141-4. doi: 10.1136/emj.2002.001578.
10
Cerebral oedema during treatment of diabetic ketoacidosis: are we any nearer finding a cause?
Diabetes Metab Res Rev. 2000 Sep-Oct;16(5):316-24. doi: 10.1002/1520-7560(2000)9999:9999<::aid-dmrr143>3.0.co;2-r.
引用本文的文献
1
Investigation of renal tubular function with newly diagnosed type 1 diabetes mellitus during diabetic ketoacidosis.糖尿病酮症酸中毒期间初诊1型糖尿病患者肾小管功能的研究
Diabetol Metab Syndr. 2024 Nov 20;16(1):276. doi: 10.1186/s13098-024-01506-6.
2
Factors associated with severe diabetic ketoacidosis in patients diagnosed with type 1 diabetes: a decade-long cross-sectional analysis.与诊断为 1 型糖尿病的患者重度糖尿病酮症酸中毒相关的因素：长达十年的横断面分析。
J Int Med Res. 2024 Oct;52(10):3000605241281654. doi: 10.1177/03000605241281654.
3
Management of diabetic ketoacidosis in children: Does early insulin glargine help improve outcomes?儿童糖尿病酮症酸中毒的管理：早期使用甘精胰岛素是否有助于改善结局？
J Diabetes. 2024 Aug;16(8):e13597. doi: 10.1111/1753-0407.13597.
4
Two- versus one-bag fluid delivery in pediatric and adolescent diabetic ketoacidosis: a systematic review and meta-analysis.儿童及青少年糖尿病酮症酸中毒中两袋与一袋液体输注的比较：一项系统评价与荟萃分析
Clin Exp Pediatr. 2024 Oct;67(10):486-497. doi: 10.3345/cep.2023.01536. Epub 2024 Jun 27.
5
Diabetic Ketoacidosis in Children and Adolescents; Diagnostic and Therapeutic Pitfalls.儿童和青少年糖尿病酮症酸中毒；诊断与治疗误区
Diagnostics (Basel). 2023 Aug 4;13(15):2602. doi: 10.3390/diagnostics13152602.
6
The role of anion gap normalization time in the management of pediatric diabetic ketoacidosis.阴离子间隙正常化时间在儿童糖尿病酮症酸中毒管理中的作用
Front Pediatr. 2023 May 30;11:1198581. doi: 10.3389/fped.2023.1198581. eCollection 2023.
7
Insulin resistance relates to DKA severity and affects insulin requirement in children with type 1 diabetes at onset.胰岛素抵抗与 DKA 严重程度相关，并影响 1 型糖尿病患儿发病时的胰岛素需求。
Pediatr Diabetes. 2022 Dec;23(8):1613-1620. doi: 10.1111/pedi.13424. Epub 2022 Oct 11.
8
Outcome of diabetic ketoacidosis among paediatric patients managed with modified DKA protocol at Tikur Anbessa specialized hospital and Yekatit 12 hospital, Addis Ababa, Ethiopia.在埃塞俄比亚亚的斯亚贝巴的提克努尔安贝萨专科医院和叶卡特 12 医院，使用改良 DKA 方案治疗的儿科患者糖尿病酮症酸中毒的结果。
Endocrinol Diabetes Metab. 2022 Sep;5(5):e363. doi: 10.1002/edm2.363. Epub 2022 Aug 9.
9
Hemorrhagic stroke: Uncommon complication of diabetic ketoacidosis in pediatric patients.出血性中风：小儿糖尿病酮症酸中毒的罕见并发症。
Radiol Case Rep. 2022 Aug 27;17(11):4059-4063. doi: 10.1016/j.radcr.2022.07.104. eCollection 2022 Nov.
10
Efficacy and Safety of Low Dose Insulin Infusion against Standard Dose Insulin Infusion in Children with Diabetic Ketoacidosis- An Open Labelled Randomized Controlled Trial.低剂量胰岛素输注与标准剂量胰岛素输注治疗儿童糖尿病酮症酸中毒的疗效和安全性——一项开放标签随机对照试验
Indian J Endocrinol Metab. 2022 Mar-Apr;26(2):173-179. doi: 10.4103/ijem.ijem_50_22. Epub 2022 Jun 6.
本文引用的文献
1
STUDIES IN DIABETIC ACIDOSIS AND COMA, WITH PARTICULAR EMPHASIS ON THE RETENTION OF ADMINISTERED POTASSIUM.糖尿病酸中毒与昏迷的研究，特别着重于输入钾的潴留情况。
J Clin Invest. 1949 Jan;28(1):1-9. doi: 10.1172/JCI102037.
2
ON DIABETIC ACIDOSIS: A Detailed Study of Electrolyte Balances Following the Withdrawal and Reestablishment of Insulin Therapy.论糖尿病酸中毒：胰岛素治疗停用及恢复后电解质平衡的详细研究
J Clin Invest. 1933 Mar;12(2):297-326. doi: 10.1172/JCI100504.
3
Diabetic ketoacidosis with intracerebral complications.
Pediatr Diabetes. 2001 Sep;2(3):109-14. doi: 10.1034/j.1399-5448.2001.002003109.x.
4
Metabolic studies in severe diabetic ketosis.重度糖尿病酮症的代谢研究
Q J Med. 1952 Apr;21(82):225-48.
5
Treatment of diabetic ketosis.
Lancet. 1952 May 17;1(6716):983-9. doi: 10.1016/s0140-6736(52)90638-7.
6
Rhabdomyolysis in diabetic ketoacidosis.糖尿病酮症酸中毒中的横纹肌溶解症。
Pediatr Diabetes. 2003 Mar;4(1):29-31. doi: 10.1034/j.1399-5448.2003.00026.x.
7
Retention of water and electrolyte during recovery in a patient with diabetic acidosis.糖尿病酸中毒患者恢复过程中的水和电解质潴留。
J Pediatr. 1952 Dec;41(6):688-96. doi: 10.1016/s0022-3476(52)80289-6.
8
Use of hypertonic saline for the treatment of altered mental status associated with diabetic ketoacidosis.
Pediatr Crit Care Med. 2003 Apr;4(2):239-42. doi: 10.1097/01.PCC.0000059340.19010.CE.
9
Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema.与糖尿病酮症酸中毒相关性脑水肿患儿不良结局相关的因素。
J Pediatr. 2002 Dec;141(6):793-7. doi: 10.1067/mpd.2002.128888.
10
Hypopituitarism following cerebral oedema with diabetic ketoacidosis.
Arch Dis Child. 2002 Oct;87(4):337-8. doi: 10.1136/adc.87.4.337.
Zotero 插件