欧洲儿科内分泌学会/劳森威尔金斯儿科内分泌学会关于儿童和青少年糖尿病酮症酸中毒的共识声明
ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents.
作者信息
Dunger D B, Sperling M A, Acerini C L, Bohn D J, Daneman D, Danne T P A, Glaser N S, Hanas R, Hintz R L, Levitsky L L, Savage M O, Tasker R C, Wolfsdorf J I
机构信息
University of Cambridge, Department of Paediatrics, Addenbrooke's Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK.
出版信息
Arch Dis Child. 2004 Feb;89(2):188-94. doi: 10.1136/adc.2003.044875.
Abstract
Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (TIDM). Mortality is predominantly related to the occurrence of cerebral oedema; only a minority of deaths in DKA are attributed to other causes. Cerebral oedema occurs in about 0.3-1% of all episodes of DKA, and its aetiology, pathophysiology, and ideal method of treatment are poorly understood. There is debate as to whether physicians treating DKA can prevent or predict the occurrence of cerebral oedema, and the appropriate site(s) for children with DKA to be managed. There is agreement that prevention of DKA and reduction of its incidence should be a goal in managing children with diabetes.
摘要
糖尿病酮症酸中毒（DKA）是1型糖尿病（TIDM）患儿发病和死亡的主要原因。死亡主要与脑水肿的发生有关；DKA中只有少数死亡归因于其他原因。脑水肿发生在所有DKA发作中的约0.3%-1%，其病因、病理生理学和理想的治疗方法尚不清楚。对于治疗DKA的医生是否能够预防或预测脑水肿的发生，以及DKA患儿的合适管理地点存在争议。人们一致认为，预防DKA并降低其发病率应是糖尿病患儿管理的一个目标。
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