Ishido S, Kinoshita Y, Kitajima N, Itoh T, Nishiyama K, Tojo M, Yano T, Inatome T, Fukuzaki H, Chiba T
Department of Medicine, Miki City Hospital, Miki Hyogoken, Japan.
Gastrointest Endosc. 1992 Nov-Dec;38(6):689-92. doi: 10.1016/s0016-5107(92)70565-3.
The effects of sedation by intravenous fentanyl on the rate-pressure product (pulse rate x systolic blood pressure/100), arterial oxygen saturation, electrocardiographic change, and serum cortisol concentration were studied during gastroduodenoscopy in 84 patients randomized to receive fentanyl or no intravenous sedative (controls). Fentanyl administration increased the tolerance of patients and attenuated the endoscopy-induced rise in rate-pressure product and serum cortisol concentration. Desaturation of arterial oxygen was minimal and there was no difference in arterial oxygen saturation between the fentanyl group and the control group. Therefore, fentanyl appears to be a favorable sedative for upper gastrointestinal endoscopy, since its administration increased the tolerance of patients and decreased cardiac oxygen consumption.
在84例随机接受芬太尼或不接受静脉镇静剂（对照组）的患者进行胃十二指肠镜检查期间，研究了静脉注射芬太尼镇静对心率-血压乘积（脉搏率×收缩压/100）、动脉血氧饱和度、心电图变化和血清皮质醇浓度的影响。给予芬太尼提高了患者的耐受性，并减轻了内镜检查引起的心率-血压乘积和血清皮质醇浓度升高。动脉血氧去饱和程度最小，芬太尼组和对照组之间的动脉血氧饱和度无差异。因此，芬太尼似乎是上消化道内镜检查的一种理想镇静剂，因为它的使用提高了患者的耐受性并降低了心脏耗氧量。
