Kinoshita Y, Ishido S, Nishiyama K, Kitajima N, Itoh T, Inatome T, Inoh T, Fukuzaki H, Chiba T
Department of Medicine, Miki City Hospital, Hyogo-ken, Japan.
J Clin Gastroenterol. 1991 Dec;13(6):656-60. doi: 10.1097/00004836-199112000-00009.
We studied the effect of sedation by I.V. meperidine on blood pressure, pulse rate, and arterial oxygen saturation during upper gastrointestinal endoscopy. Meperidine increased the tolerance of the patients and attenuated the endoscopy-induced rise in blood pressure and pulse rate. Arterial oxygen saturation was transiently depressed in the first few minutes of the endoscopic procedure even without sedation, and meperidine administration did not aggravate this oxygen desaturation. Therefore, meperidine may be a favorable sedative for upper gastrointestinal endoscopy because its treatment increases the tolerance of patients and decreases cardiac oxygen demand without decreasing arterial oxygen saturation.
我们研究了静脉注射哌替啶镇静对上消化道内镜检查期间血压、脉搏率和动脉血氧饱和度的影响。哌替啶提高了患者的耐受性，并减轻了内镜检查引起的血压和脉搏率升高。即使不使用镇静剂，在内镜检查的最初几分钟内动脉血氧饱和度也会短暂下降，而给予哌替啶并不会加重这种氧饱和度降低。因此，哌替啶可能是上消化道内镜检查的一种理想镇静剂，因为其治疗可提高患者的耐受性并降低心脏氧需求，而不会降低动脉血氧饱和度。
