• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

细胞色素P450（BioI）（CYP107H1）介导的碳-碳键裂解

Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1).

作者信息

Cryle Max J, De Voss James J

机构信息

Department of Chemistry, University of Queensland, St. Lucia, Brisbane, Australia 4072.

出版信息

Chem Commun (Camb). 2004 Jan 7(1):86-7. doi: 10.1039/b311652b. Epub 2003 Nov 17.

DOI:10.1039/b311652b
PMID:14737344
Abstract

Cytochrome p450(BioI)(CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional p450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.

摘要

细胞色素P450（BioI）（CYP107H1）被认为在枯草芽孢杆菌中为生物素生物合成提供庚二酸等价物：我们在此报告，这种多功能细胞色素P450用于脂肪酸链内裂解的机制途径是通过连续形成醇和苏式二醇中间体，并且还报告了中间体可能的绝对构型。

相似文献

1
Carbon-carbon bond cleavage by cytochrome p450(BioI)(CYP107H1).细胞色素P450（BioI）（CYP107H1）介导的碳-碳键裂解
Chem Commun (Camb). 2004 Jan 7(1):86-7. doi: 10.1039/b311652b. Epub 2003 Nov 17.
2
Products of cytochrome P450(BioI) (CYP107H1)-catalyzed oxidation of fatty acids.细胞色素P450（BioI）（CYP107H1）催化脂肪酸氧化的产物。
Org Lett. 2003 Sep 4;5(18):3341-4. doi: 10.1021/ol035254e.
3
Expression, purification, and characterization of BioI: a carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis.BioI的表达、纯化及特性研究：一种参与枯草芽孢杆菌生物素生物合成的碳-碳键裂解细胞色素P450
Arch Biochem Biophys. 2000 Dec 15;384(2):351-60. doi: 10.1006/abbi.2000.2067.
4
Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.枯草芽孢杆菌细胞色素P450 BioI的热力学和生物物理特性
Biochemistry. 2004 Oct 5;43(39):12410-26. doi: 10.1021/bi049132l.
5
Selectivity in a barren landscape: the P450(BioI)-ACP complex.贫瘠景观中的选择性：P450(BioI)-ACP 复合物。
Biochem Soc Trans. 2010 Aug;38(4):934-9. doi: 10.1042/BST0380934.
6
Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.枯草芽孢杆菌细胞色素P450 CYP102A2和CYP102A3的表达、纯化及特性分析：巨大芽孢杆菌P450 BM3的黄素细胞色素同源物
Biochemistry. 2004 May 11;43(18):5474-87. doi: 10.1021/bi035904m.
7
Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis.细胞色素P450 Biol的表达、纯化及特性分析：一种参与枯草芽孢杆菌生物素合成的新型P450
J Biol Inorg Chem. 2001 Jun;6(5-6):523-33. doi: 10.1007/s007750100229.
8
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.来自一种细胞色素P450载体蛋白复合物的结构见解揭示了细胞色素P450（BioI）酰基载体蛋白复合物中特异性是如何实现的。
Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15696-701. doi: 10.1073/pnas.0805983105. Epub 2008 Oct 6.
9
Closing in on complete pathways of biotin biosynthesis.接近生物素生物合成的完整途径。
Mol Biosyst. 2011 Jun;7(6):1811-21. doi: 10.1039/c1mb05022b. Epub 2011 Mar 24.
10
Expression and characterization of the two flavodoxin proteins of Bacillus subtilis, YkuN and YkuP: biophysical properties and interactions with cytochrome P450 BioI.枯草芽孢杆菌的两种黄素氧还蛋白YkuN和YkuP的表达与特性：生物物理性质及与细胞色素P450 BioI的相互作用
Biochemistry. 2004 Oct 5;43(39):12390-409. doi: 10.1021/bi049131t.

引用本文的文献

1
Selective -Hydroxyketone Formation and Subsequent C-C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes.细胞色素P450单加氧酶催化的选择性α-羟基酮生成及随后的碳-碳键断裂
ACS Catal. 2024 Jun 7;14(11):8958-8971. doi: 10.1021/acscatal.4c01766. Epub 2024 May 28.
2
Oral exposure to benzalkonium chlorides in male and female mice reveals alteration of the gut microbiome and bile acid profile.经口暴露于雄性和雌性小鼠的苯扎氯铵会改变肠道微生物组和胆汁酸谱。
Toxicol Sci. 2024 Dec 1;202(2):265-277. doi: 10.1093/toxsci/kfae116.
3
CYP3A-Mediated Carbon-Carbon Bond Cleavages in Drug Metabolism.
CYP3A 介导的药物代谢中的碳-碳键断裂。
Biomolecules. 2024 Sep 5;14(9):1125. doi: 10.3390/biom14091125.
4
Advances and prospects in microbial production of biotin.生物素微生物生产的进展与展望。
Microb Cell Fact. 2024 May 12;23(1):135. doi: 10.1186/s12934-024-02413-1.
5
CYP3A Mediates an Unusual C(sp)-C(sp) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism.CYP3A 通过药物代谢中的邻位加成氧介导了一种不寻常的 C(sp)-C(sp) 键断裂。
Angew Chem Int Ed Engl. 2024 Jun 3;63(23):e202405197. doi: 10.1002/anie.202405197. Epub 2024 Apr 29.
6
P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds dehydrogenation of a specific acylated dipeptide substrate.在WS9326生物合成过程中，细胞色素P450介导的脱氢酪氨酸形成过程涉及特定酰化二肽底物的脱氢反应。
Acta Pharm Sin B. 2023 Aug;13(8):3561-3574. doi: 10.1016/j.apsb.2023.03.021. Epub 2023 Mar 29.
7
Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme.将 C-C 键断裂活性引入 P450 单加氧酶酶中。
J Am Chem Soc. 2023 Apr 26;145(16):9207-9222. doi: 10.1021/jacs.3c01456. Epub 2023 Apr 11.
8
A Review of Triterpenoids and Their Bioactivities.三萜类化合物及其生物活性研究进展
Biomolecules. 2022 Dec 22;13(1):24. doi: 10.3390/biom13010024.
9
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of -aminobenzoate in .通过 Fe:Mn 加氧酶的自我牺牲型酪氨酸裂解作用合成 - 氨基苯甲酸酯。
Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2210908119. doi: 10.1073/pnas.2210908119. Epub 2022 Sep 19.
10
Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target.三种神秘的 BioH 同工酶在分枝杆菌生物素合成的早期阶段被编程，这是一个有吸引力的抗结核药物靶点。
PLoS Pathog. 2022 Jul 11;18(7):e1010615. doi: 10.1371/journal.ppat.1010615. eCollection 2022 Jul.