Center for Yunnan Plateau Biological Resources Protection and Utilization, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing 655011, China.
Postgraduate Institute of Science (PGIS), University of Peradeniya, Peradeniya 20400, Sri Lanka.
Biomolecules. 2022 Dec 22;13(1):24. doi: 10.3390/biom13010024.
For centuries, has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous publications are stating that species have a variety of beneficial medicinal properties, and investigations on different metabolic regulations of species, extracts or isolated compounds have been performed both in vitro and in vivo. However, it has frequently been questioned whether is simply a dietary supplement for health or just a useful "medication" for restorative purposes. More than 600 chemical compounds including alkaloids, meroterpenoids, nucleobases, nucleosides, polysaccharides, proteins, steroids and triterpenes were extracted and identified from , with triterpenes serving as the primary components. In recent years, triterpenes and other small molecular constituents have aroused the interest of chemists and pharmacologists. Meanwhile, considering the significance of the triterpene constituents in the development of new drugs, this review describes 495 compounds from 25 species published between 1984 and 2022, commenting on their source, biosynthetic pathway, identification, biological activities and biosynthesis, together with applications of advanced analytical techniques to the characterization of triterpenoids.
千百年来，在亚洲国家， 一直被用作传统药物，用于预防和治疗各种疾病。有大量出版物指出， 属植物具有多种有益的药用特性，并且已经在体外和体内对不同的代谢调节进行了研究，包括 属植物的提取物或分离化合物。然而，人们经常质疑 属植物究竟是一种简单的健康饮食补充剂，还是一种用于恢复目的的有用“药物”。从 中已经提取并鉴定了 600 多种化学化合物，包括生物碱、梅洛萜类、核苷、核苷酸、多糖、蛋白质、甾体和三萜类，其中三萜类化合物是主要成分。近年来，三萜类化合物和其他小分子成分引起了化学家们和药理学家们的兴趣。同时，考虑到三萜类成分在新药开发中的重要性，本综述描述了 1984 年至 2022 年期间从 25 种 属植物中分离得到的 495 种化合物，对其来源、生物合成途径、鉴定、生物活性和生物合成进行了评论，并讨论了先进分析技术在三萜类化合物表征中的应用。
Zotero 插件
