由有机磷酸酯RPR-V在发育中的雏鸡中诱导产生的畸形。

Teratism induced in the developing chick by RPR-V, an organophosphate.

作者信息

Rao J V, Swamy A N, Yamin S, Rao S H, Rahman M F

机构信息

Toxicology Unit, Indian Institute of Chemical Technology, Hyderabad.

出版信息

Food Chem Toxicol. 1992 Nov;30(11):945-51. doi: 10.1016/0278-6915(92)90179-o.

DOI:10.1016/0278-6915(92)90179-o

PMID:1473787

Abstract

Fertile White Leghorn chicken eggs were injected on day 4 of incubation with 0, 0.25, 0.50 or 1.00 mg RPR-V/egg and opened on day 20 or allowed to hatch. The following parameters were examined: hatchability, growth and development, external malformations and skeletal deformities. As the dose was increased, the hatchability decreased, and the incidence of deformities increased. Staining of the skeleton with Alizarin red showed clear deformities in the embryos. The results suggest that RPR-V has teratogenic effects on chick embryos when injected on day 4 of incubation.

摘要

在孵化第4天，向可育的白来航鸡鸡蛋中分别注射0、0.25、0.50或1.00毫克/枚的RPR-V，在第20天打开鸡蛋进行检查或使其孵化。检查了以下参数：孵化率、生长发育、外部畸形和骨骼畸形。随着剂量增加，孵化率降低，畸形发生率增加。用茜素红对骨骼进行染色显示胚胎存在明显畸形。结果表明，在孵化第4天注射RPR-V时，其对鸡胚胎具有致畸作用。