Ruaux Craig G
Gastrointestinal Laboratory, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4474, USA.
Clin Tech Small Anim Pract. 2003 Nov;18(4):245-9. doi: 10.1016/S1096-2867(03)00072-0.
Acute pancreatitis is a challenging medical condition, with the potential for high mortality and comorbidity in companion animal patients. The anatomic position and relationships of the pancreas make direct observation of pancreatic pathology difficult, so the diagnosis of pancreatic disease is typically based on the measurement of biochemical markers in serum and imaging studies of the abdomen. The digestive enzymes typically used in the diagnosis of pancreatitis, amylase and lipase, have poor sensitivity and specificity. Recently, pancreas specific lipases have been purified from dogs and cats, leading to the availability of specific immunoassays for these proteins that show great promise in the diagnosis of acute pancreatitis. After the diagnosis of acute pancreatitis is established, there is a need to assess the severity of the disease to give an accurate prognosis for the patient. This article will review currently available methods used to diagnose acute pancreatitis and the ability of these methods to assess accurately the severity of the disease.
急性胰腺炎是一种具有挑战性的医学病症，在伴侣动物患者中存在高死亡率和合并症的风险。胰腺的解剖位置和毗邻关系使得直接观察胰腺病变较为困难，因此胰腺疾病的诊断通常基于血清中生化标志物的检测以及腹部影像学检查。通常用于诊断胰腺炎的消化酶，淀粉酶和脂肪酶，其敏感性和特异性较差。最近，已从犬猫体内纯化出胰腺特异性脂肪酶，从而有了针对这些蛋白质的特异性免疫测定方法，这些方法在急性胰腺炎的诊断中显示出巨大潜力。在确诊急性胰腺炎后，需要评估疾病的严重程度，以便为患者提供准确的预后判断。本文将综述目前用于诊断急性胰腺炎的方法以及这些方法准确评估疾病严重程度的能力。
