来自恰帕斯美登木的杀虫倍半萜吡啶生物碱。

Insecticidal sesquiterpene pyridine alkaloids from Maytenus chiapensis.

作者信息

Núñez Marvin J, Guadaño Ana, Jiménez Ignacio A, Ravelo Angel G, González-Coloma Azucena, Bazzocchi Isabel L

机构信息

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Canary Islands, Spain.

出版信息

J Nat Prod. 2004 Jan;67(1):14-8. doi: 10.1021/np030347q.

DOI:10.1021/np030347q

PMID:14738378

Abstract

The new sesquiterpene pyridine alkaloids chiapenines ES-I (1), ES-II (2), ES-III (3), and ES-IV (4), in addition to the known alkaloids wilfordine (5), alatamine (6), wilforidine (7), alatusinine (8), euonine (9), euonymine (10), ebenifoline E-I (11), forrestine (12), mayteine (13), and 4-hydroxy-7-epi-chuchuhuanine E-V (14), were isolated from the leaves of Maytenus chiapensis. Their structures were elucidated by 1D and 2D NMR spectroscopy, including homonuclear and heteronuclear correlation (COSY, ROESY, HSQC, and HMBC) experiments. Wilfordine, alatusinine, and euonine exhibited strong antifeedant activity against Spodoptera littoralis.

摘要

除了已知生物碱雷公藤定碱（5）、翼荚豆胺（6）、雷公藤次碱（7）、翅荚新碱（8）、卫矛宁（9）、卫矛明（10）、紫锦树宁E-I（11）、福氏卫矛碱（12）、美登木碱（13）和4-羟基-7-表-苦树碱E-V（14）外，还从墨西哥美登木的叶子中分离出了新的倍半萜吡啶生物碱奇亚平宁ES-I（1）、ES-II（2）、ES-III（3）和ES-IV（4）。通过一维和二维核磁共振光谱，包括同核和异核相关（COSY、ROESY、HSQC和HMBC）实验对它们的结构进行了阐明。雷公藤定碱、翅荚新碱和卫矛宁对棉铃虫表现出很强的拒食活性。