Beghi Ettore, Garattini Livio, Ricci Elena, Cornago Dante, Parazzini Fabio
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Epilepsia. 2004 Feb;45(2):171-8. doi: 10.1111/j.0013-9580.2004.14103.x.
To investigate the costs of epilepsy from a nationwide survey comparing adult patients included in different prognostic categories.
A 12-month prospective observational study was conducted in 15 epilepsy centers from Northern, Central, and Southern Italy. The study population included a random sample of individuals aged 18 years and older with newly diagnosed (ND) epilepsy, seizure remission (R), occasional seizures (OS), active non-drug-resistant (NDR) seizures, drug-resistant (DR) seizures, or surgical candidates (SC). Estimates of the direct costs of care of epilepsy were based on the use of diagnostic examinations, laboratory tests, specialist consultations, hospital admissions, day-hospital days, and drugs, taking the Italian National Health Service perspective.
The sample included 631 patients (ND 62, R 158, OS 155, NDR 114, DR 128, and SC 14). The SC group had the highest total cost per patient (3,619 euros) followed by DR (2,190 euros), ND (976 euros), NDR (894 euros), OS (830 euros), and R (561 euros). For each epilepsy group, the main components of the total cost were drugs and hospital admissions. Drug costs increased from the R group to the DR group. The new antiepileptic drugs (AEDs) were the largest part of the cost of treatment.
The costs of epilepsy in referral patients vary significantly according to the time course of the disease and the response to treatment. Hospital admissions and drugs are the major sources of expenditure.
通过一项全国性调查，比较不同预后类别的成年癫痫患者，以研究癫痫的成本。
在意大利北部、中部和南部的15个癫痫中心进行了一项为期12个月的前瞻性观察研究。研究人群包括年龄在18岁及以上新诊断（ND）癫痫、癫痫发作缓解（R）、偶发癫痫（OS）、活动性非耐药（NDR）癫痫、耐药（DR）癫痫或手术候选者（SC）的个体随机样本。从意大利国家卫生服务的角度出发，基于诊断检查、实验室检查、专科会诊、住院、日间医院治疗天数和药物的使用情况，对癫痫护理的直接成本进行估算。
样本包括631名患者（ND 62例、R 158例、OS 155例、NDR 114例、DR 128例和SC 14例）。SC组每位患者的总成本最高（3619欧元），其次是DR组（2190欧元）、ND组（976欧元）、NDR组（894欧元）、OS组（830欧元）和R组（561欧元）。对于每个癫痫组，总成本的主要组成部分是药物和住院。药物成本从R组到DR组有所增加。新型抗癫痫药物（AEDs）是治疗成本的最大部分。
转诊患者的癫痫成本根据疾病的病程和对治疗的反应有显著差异。住院和药物是主要的支出来源。
