Walter S
Department of Physiology, Christian Medical College, Vellore.
Indian J Physiol Pharmacol. 1992 Jul;36(3):169-73.
This study was done to identify the immediate changes induced by cigarette smoking on the mechanical properties of the lung. Static compliance (C stat), static pressure-volume (Stat P-V) hysteresis, vital capacity (VC), frequency dependence of dynamic compliance (C dyn) and collateral ventilation (Coll V) of the lung were studied in six mongrel dogs. The smoking of one cigarette induced a fall in VC and static P-V hysteresis of the lungs. These changes indicate an increase in elastic recoil of the lung probably caused by inactivation of pulmonary surfactant. Frequency dependence of C dyn did not develop after smoking. Extensive collateral ventilation was seen in the lungs of all the experimental animals and in those of five other normal dogs, who had not been exposed to cigarette smoke. The significance of these findings are discussed.
本研究旨在确定吸烟对肺力学特性的即时影响。对6只杂种狗的肺静态顺应性（C stat）、静态压力-容积（Stat P-V）滞后现象、肺活量（VC）、动态顺应性（C dyn）的频率依赖性以及肺侧支通气（Coll V）进行了研究。吸一支烟会导致肺的VC和静态P-V滞后现象下降。这些变化表明肺弹性回缩增加，这可能是由肺表面活性物质失活引起的。吸烟后未出现C dyn的频率依赖性。在所有实验动物以及另外5只未接触香烟烟雾的正常狗的肺中均观察到广泛的侧支通气。对这些发现的意义进行了讨论。
