Williams D L, Heath M F, Wallis C
Queen's Veterinary School Small Animal Hospital, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
Vet Ophthalmol. 2004 Jan-Feb;7(1):29-35. doi: 10.1111/j.1463-5224.2004.00317.x.
In this study 2000 dogs were examined ophthalmoscopically to determine presence of cataract.
The dogs examined were predominantly from veterinary hospital populations but also from the Waltham Center For Pet Nutrition, rehoming charities and breeding kennels. Prevalence of cataract was thus determined for different age groups (year cohorts). The age at which prevalence of cataract was 50% (C50) was determined indirectly from a fitted prevalence curve.
The mean +/- standard deviation of C50 for all dogs in the study was 9.4 +/- 3.3 years. All dogs over 13.5 years were affected by some degree of lens opacity. C50 was determined for animals of different genders and different breeds. For dogs of six breeds sufficient data were available for calculation of breed-specific C50. In these dogs C50 was positively correlated with longevity with a least squares correlation coefficient of 0.74.
The study yields novel findings regarding the prevalence and incidence of cataract in the dog and forms the basis for considerable further work on the epidemiology and pathophysiology of age-related cataract in the dog.
在本研究中,对2000只犬进行了检眼镜检查以确定白内障的存在情况。
所检查的犬主要来自兽医医院,但也有来自宠物营养研究中心、宠物领养慈善机构和繁殖犬舍的。由此确定了不同年龄组(年龄队列)白内障的患病率。白内障患病率为50%(C50)时的年龄是通过拟合患病率曲线间接确定的。
本研究中所有犬的C50的平均值±标准差为9.4±3.3岁。所有13.5岁以上的犬都受到了一定程度的晶状体混浊影响。确定了不同性别和不同品种动物的C50。对于六个品种的犬,有足够的数据可用于计算特定品种的C50。在这些犬中,C50与寿命呈正相关,最小二乘相关系数为0.74。
该研究得出了关于犬白内障患病率和发病率的新发现,并为进一步深入研究犬年龄相关性白内障的流行病学和病理生理学奠定了基础。