Tandon S K, Dhawan M, Kumar A, Flora S J
Industrial Toxicology Research Centre, Lucknow, U.P.
Indian J Physiol Pharmacol. 1992 Jul;36(3):201-4.
The influence of selenium supplementation during chelation therapy to reduce body burden and toxicity of lead was investigated in rats. Selenium had marginal effects on liver, kidney and blood lead decorporation by calcium disodium ethylenediamine tetra acetic acid (CaNa2EDTA) and activation of inhibited delta- aminolevulinic acid dehydratase (ALAD) activity by calcium trisodium diethylenetriamine penta acetic acid (CaNa3DTPA). Selenium supplementation however, had no influence on lead induced inhibition of renal and hepatic transaminases and alkaline phosphatase. The results suggest that selenium supplementation slightly augments lead mobilization by chelating drugs.
研究了在螯合疗法期间补充硒对降低大鼠体内铅负荷和毒性的影响。硒对用乙二胺四乙酸二钠钙（CaNa2EDTA）进行的肝脏、肾脏和血液中铅的排出以及用二乙烯三胺五乙酸三钠钙（CaNa3DTPA）激活受抑制的δ-氨基乙酰丙酸脱水酶（ALAD）活性的作用甚微。然而，补充硒对铅诱导的肾和肝转氨酶及碱性磷酸酶的抑制没有影响。结果表明，补充硒可通过螯合药物略微增强铅的动员。
