巴布亚新几内亚儿童白血病：一种不寻常的模式。

Leukaemia in children in Papua New Guinea: an unusual pattern.

作者信息

Lavu E K, Vince J D, Kiromat M, Oswyn G, Golpak P, Tefuarani N

机构信息

Division of Medical & Laboratory Sciences, School of Medicine & Health Sciences, University of Papua New Guinea, Papua New Guinea.

出版信息

Ann Trop Paediatr. 2003 Dec;23(4):265-71. doi: 10.1179/027249303225007644.

DOI:10.1179/027249303225007644

PMID:14738574

Abstract

We report data on 110 children aged <15 years diagnosed with leukaemia during two periods covering 13.25 years. The data sets were consistent. The reported incidence of leukaemia was low. Only 34 (31%) of the children were diagnosed with acute lymphoblastic leukaemia (ALL) compared with 54 (49%) children with acute myeloid leukaemia (AML). The overall mean (SD) age was 6.6 (3.5) years, 6.1 (3.5) for ALL and 6.9 (3.5) for AML. There was no evidence of an early childhood peak of ALL. The male : female ratio was 1.2 : 1 for all leukaemias, 1.3 for ALL and 1.25 for AML. Only eight (22%) of those diagnosed with ALL were classified as type L1. Our figures reflect a relative absence of the common (cALL) cell type in early childhood leukaemia and support the role of infection and its effect on the immune system in the aetiology of childhood leukaemia. Our data also revealed an unusually high proportion of chronic myeloid leukaemia (CML).

摘要

我们报告了在两个时间段（共13.25年）内确诊的110名15岁以下白血病患儿的数据。数据集是一致的。报告的白血病发病率较低。只有34名（31%）儿童被诊断为急性淋巴细胞白血病（ALL），相比之下，54名（49%）儿童被诊断为急性髓细胞白血病（AML）。总体平均（标准差）年龄为6.6（3.5）岁，ALL患儿为6.1（3.5）岁，AML患儿为6.9（3.5）岁。没有证据表明ALL在幼儿期有发病高峰。所有白血病的男女比例为1.2:1，ALL为1.3，AML为1.25。在被诊断为ALL的患儿中，只有8名（22%）被归类为L1型。我们的数据反映出幼儿白血病中常见的（cALL）细胞类型相对缺乏，并支持感染及其对免疫系统的影响在儿童白血病病因学中的作用。我们的数据还显示慢性髓细胞白血病（CML）的比例异常高。