白细胞介素-6转信号传导：备受关注。
IL-6 trans-signaling: the heat is on.
作者信息
Rose-John Stefan, Neurath Markus F
机构信息
Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24098, Kiel, Germany.
出版信息
Immunity. 2004 Jan;20(1):2-4. doi: 10.1016/s1074-7613(04)00003-2.
Abstract
The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.
摘要
最近的一项研究揭示了发热反应的分子机制，该研究表明，体温升至40摄氏度会导致白细胞与组织切片的黏附增加，这是由淋巴细胞中的L-选择素激活介导的。热反应期间这种L-选择素的激活依赖于通过可溶性IL-6R的IL-6转信号传导。
Zotero 插件