Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Medway Campus, Chatham, Kent ME44TB, UK.
J Mater Sci Mater Med. 2010 Jun;21(6):1997-2000. doi: 10.1007/s10856-010-4060-2. Epub 2010 Apr 8.
Restorative grade glass-ionomer cement has been studied for its potential as a controlled release material for the antimicrobial compound sodium fusidate. Sodium fusidate powder was incorporated into the cement at the mixing stage at levels of 1% and 5% by mass, and disc shaped specimens (6 mm diameter x 2 mm depth) prepared. After curing for 1 hour at 37 degrees C, specimens were placed in water and release of sodium fusidate at set time intervals determined using reverse-phase HPLC. Sets of five specimens were used in all experiments. Early release of sodium fusidate was shown to occur by diffusion for each level of addition, as shown by M(t)/M(infinity) being linear with respect to [square root]time in both cases. Diffusion coefficients were calculated as 4.4 x 10(-8) cm(2) s(-1) and 3.0 x 10(-8) cm(2) s(-1) for 1 and 5% respectively. These were an order of magnitude lower than had been found previously for water transport in glass-ionomer cements, a result that is attributed to the greater size of the sodium fusidate molecule compared with that of water. Cements released 20.4 and 22.8% respectively of the total sodium fusidate added after 2 weeks, values which were not significantly different from each other, and which exceeded total release previously reported for benzalkonium chloride and chlorhexidine.
研究了修复级玻璃离子水门汀作为抗菌化合物 fusidic 酸钠的控释材料的潜力。fusidic 酸钠粉末在混合阶段以 1%和 5%（质量比）的水平掺入水泥中，并制备出圆盘状试件（直径 6 毫米×深度 2 毫米）。在 37°C 下固化 1 小时后，将试件置于水中，并使用反相高效液相色谱法在设定的时间间隔确定 fusidic 酸钠的释放。在所有实验中，每组使用五个试件。通过扩散，对于每个添加水平，fusidic 酸钠的早期释放，如 M(t)/M(infinity)与 [square root]time 的关系呈线性，在两种情况下均如此。扩散系数分别计算为 4.4×10(-8)cm(2)s(-1)和 3.0×10(-8)cm(2)s(-1)，分别用于 1%和 5%。这些值比以前在玻璃离子水门汀中发现的水传输扩散系数低一个数量级，这归因于 fusidic 酸钠分子的尺寸大于水分子的尺寸。水泥在 2 周后分别释放了添加的总 fusidic 酸钠的 20.4%和 22.8%，彼此之间没有显著差异，并且超过了以前报道的苄索氯铵和洗必泰的总释放量。
