Mo X M, Xu C Y, Kotaki M, Ramakrishna S
Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore.
Biomaterials. 2004 May;25(10):1883-90. doi: 10.1016/j.biomaterials.2003.08.042.
Poly(L-lactide-co-epsilon-caprolactone) [P(LLA-CL)] with L-lactide to epsilon-caprolactone ratio of 75 to 25 has been electrospun into nanofibers. The relationship between electrospinning parameters and fiber diameter has been investigated. The fiber diameter decreased with decreasing polymer concentration and with increasing electrospinning voltage. The X-ray diffractometer and differential scanning colorimeter results suggested that the electrospun nanofibers developed highly oriented structure in CL-unit sequences during the electrospinning process. The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds.
左旋丙交酯与ε-己内酯比例为75比25的聚（左旋丙交酯-共-ε-己内酯）[P(LLA-CL)]已被静电纺丝成纳米纤维。研究了静电纺丝参数与纤维直径之间的关系。纤维直径随聚合物浓度的降低和静电纺丝电压的升高而减小。X射线衍射仪和差示扫描量热仪的结果表明，静电纺纳米纤维在静电纺丝过程中CL单元序列形成了高度取向的结构。通过在纳米纤维支架上培养细胞，研究了纳米纤维支架的生物相容性。平滑肌细胞和内皮细胞在P(LLA-CL)纳米纤维支架上均能良好地黏附并增殖。
