Muroi Hisae, Nihei Ken-ichi, Tsujimoto Kazuo, Kubo Isao
Department of Environmental Science, Policy and Management, University of California at Berkeley, CA 94720-3112, USA.
Bioorg Med Chem. 2004 Feb 1;12(3):583-7. doi: 10.1016/j.bmc.2003.10.046.
The synergistic effects of 6-alk(en)ylsalcylic acids, also known as anacardic acids, in combination with methicillin against Staphylococcus aureus ATCC 33591 (MRSA) was investigated. The double bond in C15-anacardic acids is not essential in eliciting the antibacterial activity but is associated with increasing the activity. The synergistic effects decreased with increasing the number of double bonds in the alkyl chain. On the other hand, the antibacterial activity of anacardic acids possessing different alkyl chain lengths against the same MRSA strain was found to be a parabolic function of their lipophilicity and maximized with the alkyl chain length of C10 and C12. Notably, the synergistic effects were noted to increase with increasing the alkyl chain length.
研究了6-烷（烯）基水杨酸（又称漆树酸）与甲氧西林联合对金黄色葡萄球菌ATCC 33591（耐甲氧西林金黄色葡萄球菌）的协同作用。C15-漆树酸中的双键在引发抗菌活性方面并非必不可少，但与活性增加有关。协同作用随着烷基链中双键数量的增加而降低。另一方面，发现具有不同烷基链长度的漆树酸对同一耐甲氧西林金黄色葡萄球菌菌株的抗菌活性是其亲脂性的抛物线函数，并且在烷基链长度为C10和C12时达到最大值。值得注意的是，协同作用随着烷基链长度的增加而增加。
