Tordjman Joan, Khazen Wael, Antoine Bénédicte, Chauvet Geneviève, Quette Joelle, Fouque Françoise, Beale Elmus G, Benelli Chantal, Forest Claude
UMR-S 530 Inserm-Université René Descartes, centre Universitaire-U.F.R. Biomédicale, 45, rue des Saints-Pères, 75006 Paris, France.
Biochimie. 2003 Dec;85(12):1213-8. doi: 10.1016/j.biochi.2003.11.010.
Recent studies brought adipocyte glyceroneogenesis back to the fore as an important pathway in fatty acid homeostasis and underlined the key role played by cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C gene transcription and glyceroneogenesis and describes evidence for disregulation of this pathway in type 2 diabetes.
最近的研究使脂肪细胞甘油生成重新成为脂肪酸稳态中的一条重要途径，并强调了胞质磷酸烯醇式丙酮酸羧激酶（PEPCK-C）在该途径中所起的关键作用。本综述分析了一系列激素和营养素影响PEPCK-C基因转录及甘油生成的机制，并描述了2型糖尿病中该途径失调的证据。
