脂肪酸、视黄酸和噻唑烷二酮对甘油异生和磷酸烯醇式丙酮酸羧激酶的调节：与2型糖尿病的潜在关联
Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.
作者信息
Tordjman Joan, Khazen Wael, Antoine Bénédicte, Chauvet Geneviève, Quette Joelle, Fouque Françoise, Beale Elmus G, Benelli Chantal, Forest Claude
机构信息
UMR-S 530 Inserm-Université René Descartes, centre Universitaire-U.F.R. Biomédicale, 45, rue des Saints-Pères, 75006 Paris, France.
出版信息
Biochimie. 2003 Dec;85(12):1213-8. doi: 10.1016/j.biochi.2003.11.010.
Recent studies brought adipocyte glyceroneogenesis back to the fore as an important pathway in fatty acid homeostasis and underlined the key role played by cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C gene transcription and glyceroneogenesis and describes evidence for disregulation of this pathway in type 2 diabetes.
最近的研究使脂肪细胞甘油生成重新成为脂肪酸稳态中的一条重要途径，并强调了胞质磷酸烯醇式丙酮酸羧激酶（PEPCK-C）在该途径中所起的关键作用。本综述分析了一系列激素和营养素影响PEPCK-C基因转录及甘油生成的机制，并描述了2型糖尿病中该途径失调的证据。
Zotero 插件