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Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter.水通道蛋白7（脂肪甘油转运蛋白）缺失后的肥胖与代谢紊乱
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10759-60. doi: 10.1073/pnas.0504965102. Epub 2005 Jul 26.
2
Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.水通道蛋白7缺乏通过激活脂肪甘油激酶与肥胖的发生有关。
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10993-8. doi: 10.1073/pnas.0503291102. Epub 2005 Jul 11.
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Glycerol transport: an additional target for obesity therapy?甘油转运：肥胖治疗的另一个靶点？
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Obesity: aquaporin enters the picture.肥胖：水通道蛋白进入了人们的视野。
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Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice.水通道蛋白7在小鼠脂肪积累病理生理调控中的作用
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Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.脂肪组织中通过水通道蛋白7进行甘油转运以适应禁食。
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Apelin-13 decreases lipid storage in hypertrophic adipocytes in vitro through the upregulation of AQP7 expression by the PI3K signaling pathway.Apelin-13通过PI3K信号通路上调水通道蛋白7（AQP7）的表达，从而在体外减少肥大脂肪细胞中的脂质储存。
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High intraocular pressure is associated with cardiometabolic risk factors in South Korean men: Korean National Health and Nutrition Examination Survey, 2008-2010.高眼压与韩国男性的心血管代谢危险因素相关：2008 - 2010年韩国国民健康与营养检查调查
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本文引用的文献

1
Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.水通道蛋白7缺乏通过激活脂肪甘油激酶与肥胖的发生有关。
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10993-8. doi: 10.1073/pnas.0503291102. Epub 2005 Jul 11.
2
Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.水通道蛋白7缺陷小鼠中脂肪细胞的渐进性肥大：脂肪细胞甘油通透性作为脂肪积累的一种新型调节因子。
J Biol Chem. 2005 Apr 22;280(16):15493-6. doi: 10.1074/jbc.C500028200. Epub 2005 Mar 3.
3
Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.脂肪组织中通过水通道蛋白7进行甘油转运以适应禁食。
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6. doi: 10.1073/pnas.0406230101. Epub 2004 Dec 10.
4
From structure to disease: the evolving tale of aquaporin biology.从结构到疾病：水通道蛋白生物学的演变历程
Nat Rev Mol Cell Biol. 2004 Sep;5(9):687-98. doi: 10.1038/nrm1469.
5
Central role of the adipocyte in the insulin-sensitising and cardiovascular risk modifying actions of the thiazolidinediones.脂肪细胞在噻唑烷二酮类药物的胰岛素增敏及心血管风险改善作用中的核心作用。
Biochimie. 2003 Dec;85(12):1219-30. doi: 10.1016/j.biochi.2003.10.010.
6
Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.脂肪酸、视黄酸和噻唑烷二酮对甘油异生和磷酸烯醇式丙酮酸羧激酶的调节：与2型糖尿病的潜在关联
Biochimie. 2003 Dec;85(12):1213-8. doi: 10.1016/j.biochi.2003.11.010.
7
Glyceroneogenesis and the triglyceride/fatty acid cycle.甘油异生作用与甘油三酯/脂肪酸循环。
J Biol Chem. 2003 Aug 15;278(33):30413-6. doi: 10.1074/jbc.R300017200. Epub 2003 Jun 4.
8
A futile metabolic cycle activated in adipocytes by antidiabetic agents.一种由抗糖尿病药物在脂肪细胞中激活的无效代谢循环。
Nat Med. 2002 Oct;8(10):1122-8. doi: 10.1038/nm780. Epub 2002 Sep 23.
9
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance.脂肪组织中磷酸烯醇式丙酮酸羧激酶（PEPCK）过表达导致脂肪酸再酯化增加，进而引发无胰岛素抵抗的肥胖。
Diabetes. 2002 Mar;51(3):624-30. doi: 10.2337/diabetes.51.3.624.
10
Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.水通道蛋白脂肪亚型（AQPap）的基因组结构及胰岛素介导的抑制作用，AQPap是脂肪组织特异性甘油通道。
J Biol Chem. 2001 Sep 28;276(39):36251-60. doi: 10.1074/jbc.M106040200. Epub 2001 Jul 16.

Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter.

作者信息

MacDougald Ormond A, Burant Charles F

机构信息

Departments of Molecular and Integrative Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

出版信息

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10759-60. doi: 10.1073/pnas.0504965102. Epub 2005 Jul 26.

DOI:10.1073/pnas.0504965102
PMID:16046537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1182462/
Abstract
摘要