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人格障碍是执行功能缺陷的心理表现吗?一项双胞胎研究的双变量遗传力证据。

Are personality disorders psychological manifestations of executive function deficits? Bivariate heritability evidence from a twin study.

作者信息

Coolidge Frederick L, Thede Linda L, Jang Kerry L

机构信息

University of Colorado, Colorado Springs, CO 80933-7150, USA.

出版信息

Behav Genet. 2004 Jan;34(1):75-84. doi: 10.1023/B:BEGE.0000009486.97375.53.

Abstract

This study tested whether personality disorders may be the psychological manifestations of executive function deficits by examining their bivariate heritability in a community sample of 314 twins (ages 5-17 years; M age = 9.7; 96 monozygotic pairs and 61 dizygotic pairs). The parents of the twins completed the Coolidge Personality and Neuropsychological Inventory (Coolidge, 1998; Coolidge et al., 2002). Heritability was estimated by structural equation modeling. Executive function deficits and personality disorders were significantly heritable (executive function deficits,.77; 11 out of 12 personality disorders, median =.69). The proportion of the observed correlation attributable to heritable factors or bivariate heritability between executive function deficits and the personality disorder scales ranged from.27 for schizoid to.64 for histrionic. These findings may provide some insight as to why individuals diagnosed with specific personality disorders frequently exhibit chronic difficulties with everyday decisions, selective attention and inhibition, judgments, choices, planning, and flexibility.

摘要

本研究通过在一个由314对双胞胎(年龄5 - 17岁;平均年龄 = 9.7岁;96对同卵双胞胎和61对异卵双胞胎)组成的社区样本中检验人格障碍与执行功能缺陷的双变量遗传性,来测试人格障碍是否可能是执行功能缺陷的心理表现。双胞胎的父母完成了柯立芝人格与神经心理学量表(柯立芝,1998;柯立芝等人,2002)。遗传性通过结构方程模型进行估计。执行功能缺陷和人格障碍具有显著遗传性(执行功能缺陷,遗传性为0.77;12种人格障碍中的11种,中位数为0.69)。执行功能缺陷与各人格障碍量表之间可归因于遗传因素或双变量遗传性的观察到的相关性比例,从分裂样人格障碍的0.27到表演型人格障碍的0.64不等。这些发现可能有助于理解为什么被诊断患有特定人格障碍的个体在日常决策、选择性注意与抑制、判断、选择、规划和灵活性方面经常表现出长期困难。

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