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遗传和环境因素对人格障碍维度的影响。

Genetic and environmental contributions to dimensions of personality disorder.

作者信息

Livesley W J, Jang K L, Jackson D N, Vernon P A

机构信息

Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

出版信息

Am J Psychiatry. 1993 Dec;150(12):1826-31. doi: 10.1176/ajp.150.12.1826.

Abstract

OBJECTIVE

The authors estimated the heritability of the basic dimensions of personality disorder and the relative proportions of the variance attributable to genetic and environmental sources.

METHOD

The subjects were 175 volunteer twin pairs (90 monozygotic and 85 dizygotic) from the general population. Each twin completed the Dimensional Assessment of Personality Pathology, a questionnaire that assesses 18 dimensions of personality disorder. The questionnaire was developed on the basis of factor analytic studies that identified a stable structure underlying personality disorders in clinical and nonclinical subjects. Structural equation model-fitting methods were used to estimate the influence of additive genetic, common environmental, and unique environmental effects.

RESULTS

The estimates of broad heritability ranged from 0%, for conduct problems, to 64%, for narcissism. Behaviors associated with submissiveness and attachment problems had low heritability. For most dimensions, the best-fitting model was one that specified additive genetic and unique environmental effects.

CONCLUSIONS

These results are similar to those reported for normal personality and suggest a continuity between normal and disordered personality.

摘要

目的

作者估计了人格障碍基本维度的遗传度以及可归因于遗传和环境因素的方差相对比例。

方法

研究对象为来自普通人群的175对自愿参与的双胞胎(90对同卵双胞胎和85对异卵双胞胎)。每对双胞胎都完成了人格病理学维度评估问卷,该问卷评估人格障碍的18个维度。该问卷是基于因素分析研究开发的,这些研究确定了临床和非临床受试者人格障碍背后的稳定结构。采用结构方程模型拟合方法来估计加性遗传、共同环境和独特环境效应的影响。

结果

广义遗传度估计值范围从品行问题的0%到自恋的64%。与顺从和依恋问题相关的行为遗传度较低。对于大多数维度,最佳拟合模型是指定加性遗传和独特环境效应的模型。

结论

这些结果与正常人格的报道结果相似,表明正常人格与异常人格之间存在连续性。

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