Divers Thomas J
Large Animal Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Clin North Am Equine Pract. 2003 Dec;19(3):779-90. doi: 10.1016/j.cveq.2003.08.002.
Organ thrombosis and laminitis are life-threatening complications in horses with acute gastrointestinal disease, especially those diseases that cause disruption of the protective mucosal barrier. Prevention of these complications should be a high priority when treating horses with gastrointestinal diseases because even with proper and intensive treatments, laminitis or organ thrombosis may not be curative. Preventative therapy should include expedient and appropriate treatment of the primary disease, normalization of tissue perfusion and oxygenation, and inhibition of gut-derived toxins or their systemically activated biologic products along with i.v. replacement of depleted anticoagulant proteins. Additionally, several risk factors for thrombophlebitis in horses with intestinal disease have been identified, and those risk factors should be minimized during the illness.
器官血栓形成和蹄叶炎是患有急性胃肠疾病马匹的危及生命的并发症，尤其是那些导致保护性粘膜屏障破坏的疾病。在治疗患有胃肠疾病的马匹时，预防这些并发症应是高度优先事项，因为即使进行适当和强化治疗，蹄叶炎或器官血栓形成可能也无法治愈。预防性治疗应包括对原发性疾病进行迅速且适当的治疗、使组织灌注和氧合正常化、抑制肠道来源的毒素或其全身激活的生物产物，以及静脉内补充消耗的抗凝蛋白。此外，已确定患有肠道疾病马匹发生血栓性静脉炎的若干风险因素，在患病期间应尽量减少这些风险因素。
