Tricomi Elizabeth M, Delgado Mauricio R, Fiez Julie A
Department of Psychology, University of Pittsburgh, PA 15260, USA.
Neuron. 2004 Jan 22;41(2):281-92. doi: 10.1016/s0896-6273(03)00848-1.
Research has increasingly implicated the striatum in the processing of reward-related information in both animals and humans. However, it is unclear whether human striatal activation is driven solely by the hedonic properties of rewards or whether such activation is reliant on other factors, such as anticipation of upcoming reward or performance of an action to earn a reward. We used event-related functional magnetic resonance imaging to investigate hemodynamic responses to monetary rewards and punishments in three experiments that made use of an oddball paradigm. We presented reward and punishment displays randomly in time, following an anticipatory cue, or following a button press response. Robust and differential activation of the caudate nucleus occurred only when a perception of contingency existed between the button press response and the outcome. This finding suggests that the caudate is involved in reinforcement of action potentially leading to reward, rather than in processing reward per se.
研究越来越多地表明，纹状体在动物和人类处理与奖励相关的信息过程中发挥作用。然而，尚不清楚人类纹状体激活是否仅由奖励的享乐属性驱动，或者这种激活是否依赖于其他因素，如对即将到来的奖励的预期或为获得奖励而执行的动作。我们使用事件相关功能磁共振成像，在三个利用奇球范式的实验中研究对金钱奖励和惩罚的血液动力学反应。我们在预期提示后、按钮按下反应后或随机时间呈现奖励和惩罚显示。仅当按钮按下反应与结果之间存在意外之感时，尾状核才会出现强烈且不同的激活。这一发现表明，尾状核参与了可能导致奖励的行动强化，而不是奖励本身的处理。
