Chew S K, Monteiro E H, Lim Y S, Allen D M
Communicable Disease Centre, Singapore.
J Infect. 1992 Nov;25(3):267-71. doi: 10.1016/0163-4453(92)91519-h.
A prospective, open and non-randomised clinical trial using a 7-day short course of oral ciprofloxacin 500 mg twice daily was conducted on 25 adult patients with bacteraemic enteric fever. Twenty-four patients (96%) were cured and there was one treatment failure. Two patients with typhoid fever relapsed 6 weeks after finishing treatment. Defervescence of fever was rapid (median: 4 days) and the duration of hospitalisation was short (median: 8 days). Both factors resulted in patient satisfaction. A short-course regime of ciprofloxacin for the treatment of enteric fever, is therefore, highly promising.
对25例患菌血症型肠热病的成年患者进行了一项前瞻性、开放性、非随机临床试验，采用口服环丙沙星500毫克、每日两次、为期7天的短疗程治疗方案。24例患者（96%）治愈，1例治疗失败。2例伤寒热患者在完成治疗6周后复发。发热消退迅速（中位数：4天），住院时间短（中位数：8天）。这两个因素都提高了患者满意度。因此，环丙沙星短疗程治疗方案治疗肠热病很有前景。
