Mathai D, Kudva G C, Keystone J S, Kozarsky P E, Jesudason M V, Lalitha M K, Kaur A, Thomas M, John J, Pulimood B M
Department of Medicine, Christian Medical College and Hospital, Vellore, India.
J Assoc Physicians India. 1993 Jul;41(7):428-30.
A short course of ciprofloxacin, 750 mgm b.i.d. for 7 days was found to be effective in the treatment of enteric fever in 21 hospitalized patients with S.typhi (18) and S.paratyphi A(3). Median time for fever response was 3 days. All isolates were susceptible to ciprofloxacin (MIC 0.0078-0.062 mcgm/ml). The mean serum peak and trough levels were 5.4 and 1.6 mcgm/ml respectively. Stool cultures were free of Salmonellae on follow up (11-24 weeks). Two developed recurrence of paratyphoid fever, 17 days and 4 months after therapy.
发现短期服用环丙沙星（750毫克，每日两次，共7天）对21例住院的伤寒沙门菌（18例）和甲型副伤寒沙门菌（3例）感染的肠热症患者有效。发热反应的中位时间为3天。所有分离菌株对环丙沙星敏感（最低抑菌浓度为0.0078 - 0.062微克/毫升）。血清平均峰浓度和谷浓度分别为5.4微克/毫升和1.6微克/毫升。随访（11 - 24周）时粪便培养未检出沙门菌。两名患者在治疗后17天和4个月出现副伤寒热复发。
