Goldman Ran D, Ko Karen, Linett Lauren J, Scolnik Dennis
Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ann Pharmacother. 2004 Jan;38(1):146-50. doi: 10.1345/aph.1C391.
To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children.
Searches of MEDLINE (1966-November 2003) and EMBASE (1988-November 2003) were conducted using the terms ibuprofen and acetaminophen. Bibliographies of selected articles were reviewed.
Ibuprofen was significantly more effective than acetaminophen in reducing fever after a single dose. Ibuprofen was found to be more effective after 6 hours, but not after a longer period of time. Studies with multiple doses have also failed to show that one drug is better than the other.
The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.
评估布洛芬与对乙酰氨基酚相比，在发热儿童中的退热效果及安全性。
使用布洛芬和对乙酰氨基酚检索MEDLINE（1966年至2003年11月）和EMBASE（1988年至2003年11月）。对所选文章的参考文献进行了审查。
单次给药后，布洛芬在退热方面明显比对乙酰氨基酚更有效。布洛芬在6小时后更有效，但在更长时间后则不然。多剂量研究也未能表明一种药物比另一种更好。
对乙酰氨基酚和布洛芬在推荐剂量下的疗效相似，布洛芬显示出稍多的有益效果。
