Tippett Lynette J, Gendall Angela, Farah Martha J, Thompson-Schill Sharon L
Department of Psychology, University of Auckland, Auckland, New Zealand.
Neuropsychology. 2004 Jan;18(1):163-73. doi: 10.1037/0894-4105.18.1.163.
Selection ability (selecting a response from several competing semantic and/or lexical representations) was tested in 21 participants with Alzheimer's disease (AD) and 28 control participants to help clarify the nature of semantic impairments in AD. Selection demands were manipulated in 3 tasks (lexical fluency, comparison, and verb generation). In each, high-selection conditions required response selection from competing alternatives, whereas low-selection conditions had a reduced need for selection. Patients with AD were disproportionately impaired on the high-selection conditions of all tasks, even when this condition was easier. Selection deficits on verb generation were evident only relative to nonspeeded controls. Overall results indicate impaired semantic selection abilities in AD, which may contribute to poor performance on some semantic tasks.
为了帮助阐明阿尔茨海默病（AD）患者语义损伤的本质，对21名阿尔茨海默病患者和28名对照参与者进行了选择能力测试（从几种相互竞争的语义和/或词汇表征中选择一个反应）。在三项任务（词汇流畅性、比较和动词生成）中对选择要求进行了操控。在每项任务中，高选择条件要求从相互竞争的选项中进行反应选择，而低选择条件对选择的需求较少。即使在高选择条件更容易的情况下，AD患者在所有任务的高选择条件下仍受到不成比例的损伤。动词生成任务中的选择缺陷仅相对于非限时控制组而言较为明显。总体结果表明AD患者的语义选择能力受损，这可能导致在某些语义任务上表现不佳。
