被散射掩盖的吸收体的频域成像

Frequency domain imaging of absorbers obscured by scattering.

作者信息

Sevick E M, Lakowicz J R, Szmacinski H, Nowaczyk K, Johnson M L

机构信息

Department of Chemical Engineering, Vanderbilt University, Nashville, TN 37235.

出版信息

J Photochem Photobiol B. 1992 Oct 30;16(2):169-85. doi: 10.1016/1011-1344(92)80007-i.

DOI:10.1016/1011-1344(92)80007-i

PMID:1474425

Abstract

Multiple pixel, frequency domain measurements of phase shift, theta, and modulation, m, in a phantom containing an absorber obscured by a relatively non-absorbing scattering solution are presented in combination with a theory of photon migration imaging. Results employing a single point source show that two dimensional theta measurements made in the presence (theta presence) and in the absence (theta absence) of an absorber can be used to create delta theta images. delta theta (theta absence-theta presence) images can be used to detect as well as locate the three dimensional position of the absorber. Images of mpresence measured in the presence of the absorber normalized by mabsence also provided detection and two dimensional location of its position. Images of % mpresence/mabsence at higher modulation frequencies provided greater resolution as predicted by photon migration theory. Neither theta nor m images alone could be used to detect or locate the presence of the absorber.

摘要

本文结合光子迁移成像理论，展示了在含有被相对非吸收性散射溶液掩盖的吸收体的体模中，对多个像素进行相移（θ）和调制（m）的频域测量结果。采用单点源的结果表明，在有吸收体存在（θ presence）和不存在（θ absence）的情况下进行的二维θ测量可用于创建Δθ图像。Δθ（θ absence - θ presence）图像可用于检测并定位吸收体的三维位置。在有吸收体存在时测量的m presence图像，通过m absence进行归一化处理，也能检测并给出其位置的二维定位。在较高调制频率下的% m presence / m absence图像，如光子迁移理论所预测的那样，提供了更高的分辨率。单独的θ图像或m图像都无法用于检测或定位吸收体的存在。