Nakayama Kazuhisa, Wakatsuki Soichi
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida-shimoadachi, Sakyo-ku, Kyoto 606-8501, Japan.
Cell Struct Funct. 2003 Oct;28(5):431-42. doi: 10.1247/csf.28.431.
GGAs (Golgi-localizing, gamma-adaptin ear homology domain, ARF-binding proteins) are a family of monomeric clathrin adaptor proteins that are conserved from yeasts to humans. Data published during the past four years have provided detailed pictures of the localization, domain organization and structure-function relationships of GGAs. GGAs possess four conserved functional domains, each of which interacts with cargo proteins including mannose 6-phosphate receptors, the small GTPase ARF, clathrin, or accessory proteins including Rabaptin-5 and gamma-synergin. Together with or independent of the adaptor protein complex AP-1, GGAs regulate selective transport of cargo proteins, such as mannose 6-phosphate receptors, from the trans-Golgi network to endosomes mediated by clathrin-coated vesicles.
GGA蛋白（高尔基体定位、γ-衔接蛋白耳同源结构域、ARF结合蛋白）是一类单体网格蛋白衔接蛋白家族，从酵母到人类都保守存在。过去四年发表的数据提供了GGA蛋白的定位、结构域组织和结构-功能关系的详细图景。GGA蛋白具有四个保守的功能结构域，每个结构域都与货物蛋白相互作用，包括甘露糖6-磷酸受体、小GTP酶ARF、网格蛋白，或与包括Rabaptin-5和γ-协同蛋白在内的辅助蛋白相互作用。GGA蛋白与衔接蛋白复合物AP-1一起或独立发挥作用，调节货物蛋白（如甘露糖6-磷酸受体）从反式高尔基体网络到由网格蛋白包被小泡介导的内体的选择性运输。
