Oh Kil Chan, Park Sang Hoon, Baek Seung Hoon, Park Chul Hee, Hahn Tae Ho, Lee Dong Keun, Yeon Jong Eun, Kim Jong Hyeok, Byun Kwan Soo, Park Choong Kee, Lee Chang Hong
Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea.
Korean J Gastroenterol. 2004 Jan;43(1):61-5.
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/mm(3) or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and any case presenting as a large single mass lesion has not been described. Herein we report a case of hypereosinophilic syndrome with hepatic involvement in a 48-year-old woman who presented with a giant single mass. By abdominal CT scan, a lobulated well-margined heterogenous mass lesion was detected in the left lateral segment of the liver. Liver biopsy revealed severe eosinophilic infiltration and centrilobular necrosis of hepatocytes. The lesion completely disappeared after steroid administration for eleven months.
高嗜酸性粒细胞综合征的特征是在无已知病因的情况下，持续性血液嗜酸性粒细胞增多至1500/mm³或更高，并因嗜酸性粒细胞相关的组织损伤导致多器官功能障碍。在韩国，已有一些肝受累的高嗜酸性粒细胞综合征病例被描述为具有长期良性临床病程。在影像学研究中，大多数病例表现为弥漫性或多灶性病变，尚未有呈现为单个大肿块病变的病例报道。在此，我们报告一例48岁女性肝受累的高嗜酸性粒细胞综合征病例，该患者表现为单个巨大肿块。通过腹部CT扫描，在肝脏左外侧段检测到一个分叶状、边界清晰的不均匀肿块病变。肝脏活检显示肝细胞严重嗜酸性浸润和小叶中心坏死。在给予类固醇治疗11个月后，病变完全消失。
