Rossi Angela Cristina, Di Vagno Giovanni, Cormio Gennaro, Cazzolla Ambrogio, Stefanelli Sergio, D'Elia Emanuela, Selvaggi Luigi
Gynecological Oncology Unit, University of Bari, Via Celentano 42, 70121 Bari, Italy.
Arch Gynecol Obstet. 2004 May;269(4):263-5. doi: 10.1007/s00404-002-0404-6. Epub 2004 Jan 24.
The aim of our study was to investigate preoperative serum CA 125 as a prognostic factor in patients with ovarian carcinoma.
A retrospective analysis was conducted on 82 patients with ovarian carcinoma treated at our Unit between 1998 and 2000 who had a serum CA 125, evaluated by a commercially available radioimmunoassay, prior to cytoreductive surgery. We looked for an association between preoperative CA 125 and known prognostic factors of ovarian cancer. We compared outcomes of patients with preoperative CA 125 at or below to 500 U/ml with outcomes of patients with preoperative CA 125 above 500 U/ml.
A significant ( p<0.002) correlation between stage and CA 125 serum levels was found as 16 out of 18 stage I-II patients (89%) had CA 125 level </=500 U/ml and 36 out of 64 stage III-IV patients (56%) had CA 125 level >500 U/ml. Among stage III and IV patients there was nonstatistically significant relation between serum CA 125 and histologic grade (G1+G2 vs. G3) and residual disease (<1 cm vs. >1 cm) after primary cytoreductive surgery. Preoperative serum CA-125 level did not predict either recurrences or disease free interval.
Preoperative CA 125 correlated well with FIGO stage but not with age, grade, residual disease after primary surgery, relapse and disease free interval.
我们研究的目的是调查术前血清CA 125作为卵巢癌患者的一个预后因素。
对1998年至2000年间在我院接受治疗的82例卵巢癌患者进行回顾性分析，这些患者在减瘤手术前通过商用放射免疫测定法检测了血清CA 125。我们寻找术前CA 125与已知卵巢癌预后因素之间的关联。我们比较了术前CA 125低于或等于500 U/ml的患者与术前CA 125高于500 U/ml的患者的预后情况。
发现分期与CA 125血清水平之间存在显著相关性（p<0.002），因为18例I-II期患者中有16例（89%）的CA 125水平≤500 U/ml，64例III-IV期患者中有36例（56%）的CA 125水平>500 U/ml。在III期和IV期患者中，血清CA 125与组织学分级（G1+G2与G3）以及初次减瘤手术后的残留病灶（<1 cm与>1 cm）之间无统计学显著关系。术前血清CA-125水平既不能预测复发情况，也不能预测无病生存期。
术前CA 125与国际妇产科联盟（FIGO）分期密切相关，但与年龄、分级、初次手术后的残留病灶、复发及无病生存期无关。
