Geisler J P, Miller G A, Lee T H, Harwood R M, Wiemann M C, Geisler H E
Department of Pathology, St. Vincent Hospital and Health Care Center, Indianapolis, IN 46260, USA.
J Reprod Med. 1996 Mar;41(3):140-2.
Epithelial carcinoma of the ovary has the highest death rate of any gynecologic malignancy in the developed world. The antigen CA-125 has been used over the past decade as a tumor marker for epithelial ovarian cancer and other cancers of coelomic epithelium. The object of this study was to see if the degree of elevation of preoperative CA-125 was related to length of survival in patients with epithelial ovarian carcinoma.
Eighty-two consecutive patients diagnosed with epithelial ovarian carcinoma were evaluated for their initial preoperative CA-125 level, time to recurrence, length of survival and level of primary debulking as well as International Federation of Gynecologists and Obstetricians stage, grade and histology. Ovarian tumors of low malignant potential were not included in the study. All patients had their initial surgery performed by one surgeon.
Decreased length of survival was related to the degree of elevation of CA-125 prior to initial exploratory laparotomy (P = .047). The mean initial CA-125 for patients surviving five years or more (15 patients) was 899 U/mL, with an SD of +/- 1,880 U/mL, while the CA-125 for patients surviving less than five years (67 patients) was 1,978 U/mL, with an SD of +/- 1,852 U/mL (P = .02). Increased stage of disease at initial laparotomy showed a relationship to increased CA-125 (P < .0001).
In epithelial ovarian carcinoma, high preoperative serum levels of CA-125 predict decreased length of survival.
在发达国家，卵巢上皮癌是所有妇科恶性肿瘤中死亡率最高的。在过去十年中，抗原CA - 125一直被用作上皮性卵巢癌和其他体腔上皮癌的肿瘤标志物。本研究的目的是探讨术前CA - 125的升高程度是否与上皮性卵巢癌患者的生存期相关。
对82例连续诊断为上皮性卵巢癌的患者进行评估，记录其术前初始CA - 125水平、复发时间、生存期、初次肿瘤细胞减灭术情况以及国际妇产科联盟（FIGO）分期、分级和组织学类型。低恶性潜能的卵巢肿瘤不纳入本研究。所有患者均由同一位外科医生进行初次手术。
生存期缩短与初次剖腹探查术前CA - 125的升高程度相关（P = 0.047）。存活5年或更长时间的患者（15例）术前CA - 125的平均初始值为899 U/mL，标准差为±1,880 U/mL，而存活时间不足5年的患者（67例）术前CA - 125为1,978 U/mL，标准差为±1,852 U/mL（P = 0.02）。初次剖腹探查时疾病分期增加与CA - 125升高相关（P < 0.0001）。
在上皮性卵巢癌中，术前血清CA - 125水平高预示生存期缩短。
