But I, Gorisek B
Division of Gynecologic Oncology, Maribor Teaching Hospital, Slovenia.
Gynecol Oncol. 1996 Nov;63(2):166-72. doi: 10.1006/gyno.1996.0301.
A retrospective study of 60 patients with invasive epithelial ovarian cancer was conducted. The significance of preoperative serum CA 125 level with respect to tumor grade and tumor stage was determined. Tumor grade bears a strong influence on the preoperative CA 125 level; the correlation is high and statistically significant (r = 0.74, P < 0.01). The influence of FIGO stage on preoperative CA 125 level is also significant (r = 0.51, P < 0.01), but the results of the multivariate analysis show that the influence of tumor grade on preoperative CA 125 level is stronger (P < 0.01). It is believed that tumor grade is the decisive factor dictating the level of CA 125 in a certain stage of the disease and so influences the preoperative CA 125 level. It is also believed that low preoperative antigen levels of well-differentiated ovarian carcinomas in FIGO stage I are the cause of poor sensitivity of the CA 125 test, thus limiting its applicability for screening purposes.
对60例浸润性上皮性卵巢癌患者进行了回顾性研究。确定了术前血清CA 125水平与肿瘤分级和肿瘤分期的相关性。肿瘤分级对术前CA 125水平有很大影响；相关性很高且具有统计学意义（r = 0.74，P < 0.01）。国际妇产科联盟（FIGO）分期对术前CA 125水平的影响也很显著（r = 0.51，P < 0.01），但多因素分析结果显示肿瘤分级对术前CA 125水平的影响更强（P < 0.01）。据信，肿瘤分级是决定疾病某一阶段CA 125水平的决定性因素，因此影响术前CA 125水平。还认为FIGO I期高分化卵巢癌术前抗原水平低是CA 125检测敏感性差的原因，从而限制了其在筛查中的适用性。
