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针对高型肛门直肠畸形的新生儿结肠造口术审计:发展中国家视角

An audit of neonatal colostomy for high anorectal malformation: the developing world perspective.

作者信息

Chowdhary S K, Chalapathi G, Narasimhan K L, Samujh R, Mahajan J K, Menon P, Rao K L N

机构信息

Department of Pediatric Surgery, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India.

出版信息

Pediatr Surg Int. 2004 Feb;20(2):111-3. doi: 10.1007/s00383-003-1100-8. Epub 2004 Jan 24.

Abstract

A high divided sigmoid colostomy has been recommended for staged management of high anorectal malformation. We audited our cases of neonatal colostomy for high anorectal malformation to assess its effectiveness. A retrospective study was carried out of all surgical newborns admitted with high imperforate anus as the single diagnosis at our centre between December 1998 and December 2000. Morbidity and mortality were analysed after retrospective stratification into two groups (group A: birth weight >2.5 kg; group B: birth weight <2.5 kg). The chi square test was used to test the statistical significance in terms of outcome in the two groups. Overall mortality was 16%. Group A consisted of 34 babies: 30 with divided sigmoid colostomy and four with transverse loop colostomy. One baby with a divided sigmoid colostomy died from wound complications and septicaemia (mortality 2.9%). All four babies with transverse loop colostomy done under local anaesthesia survived, despite being sick on arrival. Group B consisted of 16 babies: 15 with sigmoid colostomy and one with transverse loop colostomy, with seven deaths (44%). None of the five babies with transverse loop colostomy done under local anaesthesia died, despite being sick on arrival, whereas all eight babies who died had undergone sigmoid colostomy under general anaesthesia. The difference in the outcomes of babies in groups A and B is highly significant ( p <.01). Sick, small (<2.5 kg) and septic babies arriving late to the unit do not appear to tolerate general anaesthesia and divided sigmoid colostomy well, despite that procedure's long-term advantages. Divided sigmoid colostomy has produced excellent results in babies >2.5 kg, but in the context of the developing world and limited critical care availability, transverse loop colostomy under local anaesthesia may save lives.

摘要

对于高位肛门直肠畸形的分期治疗,有人推荐采用高位乙状结肠造口术。我们对本院新生儿高位肛门直肠畸形结肠造口术病例进行了审核,以评估其效果。对1998年12月至2000年12月期间我院收治的以高位肛门闭锁为唯一诊断的所有手术新生儿进行了回顾性研究。在将病例回顾性分层为两组(A组:出生体重>2.5kg;B组:出生体重<2.5kg)后,分析了发病率和死亡率。采用卡方检验来检验两组结局的统计学显著性。总体死亡率为16%。A组有34例婴儿:30例行乙状结肠造口术,4例行横结肠袢式造口术。1例行乙状结肠造口术的婴儿死于伤口并发症和败血症(死亡率2.9%)。所有4例行局部麻醉下横结肠袢式造口术的婴儿尽管入院时病情较重,但均存活。B组有16例婴儿:15例行乙状结肠造口术,1例行横结肠袢式造口术,7例死亡(44%)。5例行局部麻醉下横结肠袢式造口术的婴儿尽管入院时病情较重,但均未死亡,而所有8例死亡的婴儿均在全身麻醉下行乙状结肠造口术。A组和B组婴儿的结局差异具有高度显著性(p<0.01)。病情较重、体重小(<2.5kg)且发生败血症、入院较晚的婴儿似乎不能很好地耐受全身麻醉和乙状结肠造口术,尽管该手术具有长期优势。乙状结肠造口术在出生体重>2.5kg的婴儿中取得了良好效果,但在发展中国家且重症监护资源有限的情况下,局部麻醉下的横结肠袢式造口术可能挽救生命。

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