Chirdan Lohfa B, Uba Francis A, Ameh Emmanuel A, Mshelbwala Philip M
University of Jos, and Jos University Teaching Hospital, Murtala Mohammed Way, Jos, Nigeria.
Pediatr Surg Int. 2008 Apr;24(4):407-10. doi: 10.1007/s00383-008-2114-z. Epub 2008 Feb 13.
Colostomy is a life-saving procedure in newborns with high anorectal malformations (ARM). However, the procedure may be attended by complications, particularly in resource limited settings. This is an evaluation of the morbidity and mortality following colostomy for ARM in newborns in two paediatric teaching centres in a developing country. A retrospective review of 61 neonates who had colostomy for high ARM in 4 years is conducted. The babies were categorised into Group A (weight at presentation < 2.5 kg) and Group B (weight at presentation > 2.5 kg). There were 47 boys and 14 girls aged 18 h to 28 days (median 6 days). There were 23 babies in Group A; 18 had colostomy under local anaesthetic (LA), 5 of whom died while 5 had the procedure done under general anaesthetic (GA), 3 of whom died (mortality 8/23, 34.78%). Group B consisted of 38 babies, 18 had colostomy under GA, 3 died, while in 20 the procedure was under LA, 1 of who died (mortality 4/38, 10.5%). The difference in mortality between groups A and B was statistically insignificant (p < 0.056). There were no significant differences in outcome between the two groups when the type of anaesthesia or types of colostomy were considered. Surgical site infection was the most common 12/61, 19.7%. Of the 12 babies that died, 7 were due to overwhelming infections, 4 respiratory insufficiencies and 1 cyanotic heart disease. The overall procedure related mortality was therefore 7 (11.5%). None of the centres had adequate neonatal intensive care services during the period of this report. Morbidity and mortality following colostomy for ARM in newborns is still high in this setting, due largely to infective complications, particularly in babies < 2.5 kg.
结肠造口术是患有高位肛门直肠畸形(ARM)新生儿的一种挽救生命的手术。然而,该手术可能会伴有并发症,尤其是在资源有限的环境中。这是对一个发展中国家两个儿科教学中心新生儿ARM结肠造口术后发病率和死亡率的评估。对4年中接受高位ARM结肠造口术的61例新生儿进行了回顾性研究。婴儿被分为A组(就诊时体重<2.5千克)和B组(就诊时体重>2.5千克)。共有47名男孩和14名女孩,年龄在18小时至28天之间(中位数为6天)。A组有23名婴儿;18名在局部麻醉(LA)下进行结肠造口术,其中5例死亡,5例在全身麻醉(GA)下进行手术,其中3例死亡(死亡率8/23,34.78%)。B组由38名婴儿组成,18名在GA下进行结肠造口术,3例死亡,而20例在LA下进行手术,其中1例死亡(死亡率4/38,10.5%)。A组和B组之间的死亡率差异无统计学意义(p<0.056)。当考虑麻醉类型或结肠造口术类型时,两组之间的结局无显著差异。手术部位感染最为常见,共12例/61例,占19.7%。在死亡的12例婴儿中,7例死于严重感染,4例死于呼吸功能不全,1例死于青紫型心脏病。因此,总体手术相关死亡率为7例(11.5%)。在本报告期间,没有一个中心具备足够的新生儿重症监护服务。在这种情况下,新生儿ARM结肠造口术后的发病率和死亡率仍然很高,主要是由于感染性并发症,尤其是体重<2.5千克的婴儿。