Lewanczuk Richard Z, Paty Breay W, Toth Ellen L
Division of Endocrinology, University of Alberta, Edmonton, Canada.
Diabetes Care. 2004 Feb;27(2):441-7. doi: 10.2337/diacare.27.2.441.
With increasing emphasis on the recognition of the metabolic syndrome and early type 2 diabetes, a clinically useful measure of insulin resistance is desirable. The purpose of this study was to evaluate whether an index of glucose metabolism, as measured by (13)CO(2) generation from ingested [(13)C]glucose, would correlate with indexes from the hyperinsulinemic-euglycemic clamp.
A total of 26 subjects with varying degrees of insulin sensitivity underwent both the [(13)C]glucose breath test and the hyperinsulinemic-euglycemic clamp. Results from the [(13)C]glucose breath test were compared with measures of insulin sensitivity from the glucose clamp as well as with other commonly used indexes of insulin sensitivity.
There was a strong correlation between the [(13)C]glucose breath test result and the glucose disposal rate (r = 0.69, P < 0.0001) and insulin sensitivity index (r = 0.69, P < 0.0001) from the insulin clamp. The magnitude of these correlations compared favorably with QUICKI and were superior to the homeostasis model assessment.
The [(13)C]glucose breath test may provide a useful noninvasive assessment of insulin sensitivity.
随着对代谢综合征和早期2型糖尿病认识的日益重视，需要一种临床上有用的胰岛素抵抗测量方法。本研究的目的是评估通过摄入的[¹³C]葡萄糖产生¹³CO₂所测量的葡萄糖代谢指标是否与高胰岛素-正常血糖钳夹试验的指标相关。
共有26名胰岛素敏感性不同的受试者接受了[¹³C]葡萄糖呼吸试验和高胰岛素-正常血糖钳夹试验。将[¹³C]葡萄糖呼吸试验的结果与葡萄糖钳夹试验的胰岛素敏感性测量结果以及其他常用的胰岛素敏感性指标进行比较。
[¹³C]葡萄糖呼吸试验结果与胰岛素钳夹试验的葡萄糖处置率（r = 0.69，P < 0.0001）和胰岛素敏感性指数（r = 0.69，P < 0.0001）之间存在强相关性。这些相关性的强度与定量胰岛素敏感性检查指数（QUICKI）相当，且优于稳态模型评估。
[¹³C]葡萄糖呼吸试验可能为胰岛素敏感性提供一种有用的非侵入性评估方法。
