Chowdhury A Q, Miah R A, Akhtar N, Jubayer S M
Department of Microbiology, SSMC, Dhaka, Bangladesh.
Mymensingh Med J. 2004 Jan;13(1):59-62.
Serosurvillance of 650 children of clinically suspected dengue infection based on simple laboratory tests were evaluated to find out the early indicator for diagnosis of dengue infection. The study was conducted among the patients attending the Sir Salimullah Medical College (SSMC) and Mitford Hospital and Popular Diagnostic Center, Dhaka, during July 2002 to September 2002. Of these 650 suspected dengue cases, 294 were in the age group 1-5 years, 206 were in age group 6-10 years and 150 cases in age group 11-15 years, of which Seropositivity was found in 78 (26.53%), 60 (24.12%) and 65 (43.33%) cases respectively. Primary dengue IgM was positive in 123 (60.59%) cases and secondary dengue (IgG & IgM combined or IgG alone) was positive in 80 (39.41%) cases. Leucopenia was found in 90 (75%) cases and Thrombocytopenia was found in 95 (79.16%) cases in primary dengue cases. Similarly in secondary dengue cases TWBC and PLT was decreased in 60 (72.29%) and 65 (78.15%) cases respectively. Haemoconcentration was found in 40 (36.67%) cases of primary dengue and 13 (18%) cases in secondary dengue. Month wise distribution of dengue seropositivity shows that 10 (8.53%) cases was found in July, 175 (50.10%) cases in August and 78 (10.00%) cases in September. This study reveals that seropositivity is highest (43.33%), in the age group 11-15 years and incidence of dengue increased in the month of August. Leucopenia (WBC <or= 5000) and Thrombocytopenia (Patelet count <or= 100000) were two findings that help in the early diagnosis of dengue infection.
基于简单实验室检测，对650名临床疑似登革热感染儿童进行血清学监测，以找出登革热感染诊断的早期指标。该研究于2002年7月至2002年9月在达卡的萨利姆拉赫爵士医学院（SSMC）、米特福德医院和大众诊断中心就诊的患者中进行。在这650例疑似登革热病例中，1 - 5岁年龄组有294例，6 - 10岁年龄组有206例，11 - 15岁年龄组有150例，其中血清阳性分别在78例（26.53%）、60例（24.12%）和65例（43.33%）中被发现。原发性登革热IgM在123例（60.59%）中呈阳性，继发性登革热（IgG和IgM联合或仅IgG）在80例（39.41%）中呈阳性。在原发性登革热病例中，90例（75%）发现白细胞减少，95例（79.16%）发现血小板减少。同样，在继发性登革热病例中，60例（72.29%）全血细胞和65例（78.15%）血小板减少。在原发性登革热40例（36.67%）和继发性登革热13例（18%）中发现血液浓缩。按月份划分的登革热血清阳性分布显示，7月发现10例（8.53%），8月发现175例（50.10%），9月发现78例（10.00%）。该研究表明，11 - 15岁年龄组血清阳性率最高（43.33%），登革热发病率在8月上升。白细胞减少（白细胞计数≤5000）和血小板减少（血小板计数≤100000）是有助于早期诊断登革热感染的两项发现。
