Badreddine Samar, Al-Dhaheri Fahmi, Al-Dabbagh Ammar, Al-Amoudi Abdulrahman, Al-Ammari Maged, Elatassi Nader, Abbas Haytham, Magliah Rami, Malibari Abdulbasit, Almoallim Hani
Department of Medicine, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2017 Oct;38(10):1025-1033. doi: 10.15537/smj.2017.10.20965.
To delineate the clinical features and outcomes of dengue infection and to guide clinician of early diagnosis and identification of risks factors for dengue hemorrhagic fever. Methods: This study is a retrospective cross-sectional. Clinical records of 567 patients with a confirmed diagnosis of dengue infection, admitted to a single hospital in Jeddah, Saudi Arabia, between January 2010 and June 2014 were reviewed. Results: Dengue infection was most common in adult males. Sixty-eight percent of infections were in Saudi nationals. In addition to the diagnostic clinical features, leucopenia and thrombocytopenia were typical of dengue infection. Approximately 4.1% of adult patients and 7.1% of pediatric patients developed dengue hemorrhagic fever (DHF). Abdominal pain and vomiting were more common in patients developing DHF. Mean platelet count was lower in adult, but not pediatric patients developing DHF. Peak alanine aminotransferase (ALT) was higher in adult and pediatric patients developing DHF. Three patients died, 2 of them developed DHF. Ninety-eight percent of adult patients and 92% of pediatric patients made a full recovery. Conclusions: Dengue infection is common in Jeddah. Abdominal pain and vomiting, thrombocytopenia, and elevated ALT are typical of severe infection, which is more likely to be associated with significant morbidity and mortality.
明确登革热感染的临床特征和结局，以指导临床医生对登革出血热进行早期诊断并识别危险因素。方法：本研究为回顾性横断面研究。回顾了2010年1月至2014年6月期间在沙特阿拉伯吉达的一家医院住院的567例确诊为登革热感染患者的临床记录。结果：登革热感染在成年男性中最为常见。68%的感染病例为沙特国民。除了诊断性临床特征外，白细胞减少和血小板减少是登革热感染的典型表现。约4.1%的成年患者和7.1%的儿科患者发生了登革出血热（DHF）。腹痛和呕吐在发生DHF的患者中更为常见。发生DHF的成年患者平均血小板计数较低，但儿科患者并非如此。发生DHF的成年和儿科患者谷丙转氨酶（ALT）峰值较高。3例患者死亡，其中2例发生了DHF。98%的成年患者和92%的儿科患者完全康复。结论：登革热感染在吉达很常见。腹痛、呕吐、血小板减少和ALT升高是严重感染的典型表现，严重感染更有可能伴有显著的发病率和死亡率。
