通过脱羧钯化和芳基碘插入形成的芳基钯中间体实现2-环烯-1-酮的Heck型芳基化反应。
Heck-type arylation of 2-cycloalken-1-ones with arylpalladium intermediates formed by decarboxylative palladation and by aryl iodide insertion.
作者信息
Tanaka Daisuke, Myers Andrew G
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
Org Lett. 2004 Feb 5;6(3):433-6. doi: 10.1021/ol0363467.
[reaction: see text] A palladium-catalyzed decarboxylative arylation reaction was shown to produce Heck-type coupling products using a number of different arene carboxylic acid and 2-cycloalken-1-one substrates. The more conventional Heck coupling of an aryl iodide and a 2-cycloalken-1-one reactant was also briefly explored for comparison, where it was found that phosphine-free (Jeffery) conditions afforded the highest yield of product.
[反应：见正文] 已表明，钯催化的脱羧芳基化反应可使用多种不同的芳烃羧酸和2-环烯-1-酮底物生成Heck型偶联产物。还简要探索了芳基碘化物与2-环烯-1-酮反应物的更传统的Heck偶联反应以作比较，结果发现无膦（杰弗里）条件下产物的产率最高。
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