膜胆固醇与信号转导的调控
Membrane cholesterol and the regulation of signal transduction.
作者信息
Fielding C J, Fielding P E
机构信息
Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, CA 94143, USA.
出版信息
Biochem Soc Trans. 2004 Feb;32(Pt 1):65-9. doi: 10.1042/bst0320065.
PMID:14748714
Abstract
The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent evidence suggests that transient changes in cholesterol content may be important in regulating signal transduction.
摘要
哺乳动物细胞的质膜由脂质和蛋白质组成不同的微结构域构成。两类不同的胆固醇/鞘脂微结构域（小窝和脂筏）是跨膜信号复合物的组装点。最近的证据表明，胆固醇含量的瞬时变化可能在调节信号转导中起重要作用。
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