Engelmann B
Vaskuläre Biologie und Hämostase, Institut für Klinische Chemie, Ludwig-Maximilians-Universität, 81377 München, Germany.
Biochem Soc Trans. 2004 Feb;32(Pt 1):147-50. doi: 10.1042/bst0320147.
Cellular membranes and plasma lipoproteins are less efficiently protected against oxidative stress than the various aqueous compartments of mammalian organisms. Here, previous results on the role of plasmalogens in lipid oxidation are evaluated on the basis of criteria required for an antioxidant. The plasmalogen-specific enol ether double bond is targeted by a vast variety of oxidants, including peroxyl radicals, metal ions, singlet oxygen and halogenating species. Oxidation of the vinyl ether markedly prevents the oxidation of highly polyunsaturated fatty acids, and products of plasmalogen degradation do not propagate lipid oxidation. This protection is also demonstrated intramolecularly, thus ascertaining the function of plasmalogens as a major storage pool for polyunsaturated fatty acids. Although cells rapidly incorporate and synthesize plasmalogens de novo, their plasmalogen contents can be deliberately increased by supplementation with precursors. Thus plasmalogens terminate lipid-oxidation processes, are present in adequate locations at sufficient concentrations, and are rapidly regenerated, classifying them as efficient antioxidants in vitro. Future work should address the in vivo role of plasmalogens in lipid oxidation and the biological function of plasmalogen interactions with oxidants.
与哺乳动物机体的各种水相区室相比，细胞膜和血浆脂蛋白对氧化应激的保护效率较低。在此，基于抗氧化剂所需的标准，对之前关于缩醛磷脂在脂质氧化中作用的结果进行评估。缩醛磷脂特有的烯醚双键受到多种氧化剂的靶向作用，包括过氧自由基、金属离子、单线态氧和卤化物质。乙烯基醚的氧化显著阻止了高度多不饱和脂肪酸的氧化，并且缩醛磷脂降解产物不会促进脂质氧化。这种保护作用在分子内也得到了证实，从而确定了缩醛磷脂作为多不饱和脂肪酸主要储存库的功能。尽管细胞能迅速从头摄取并合成缩醛磷脂，但其缩醛磷脂含量可通过补充前体物质而有意增加。因此，缩醛磷脂可终止脂质氧化过程，以足够的浓度存在于适当的位置，并能迅速再生，这使其在体外被归类为高效抗氧化剂。未来的工作应关注缩醛磷脂在体内脂质氧化中的作用以及缩醛磷脂与氧化剂相互作用的生物学功能。
