Lake S L, Laird N M
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ann Hum Genet. 2004 Jan;68(Pt 1):55-64. doi: 10.1046/j.1529-8817.2003.00073.x.
As knowledge of the human genome continues to grow, more progress is being made towards not only identifying the genes involved in disease susceptibility but also in defining the synergistic role genes play with environmental exposures. The detection of gene-environment interactions is important as it can offer clinicians a potential means of intervention. The discovery of interactions relies heavily on powerful statistical methods. We present a test, FBAT-I, that can be used to investigate gene-environment interaction. The test uses the case-parent triad design and protects the statistical inference from potential spurious results due to population admixture.
随着对人类基因组的了解不断增加，不仅在识别与疾病易感性相关的基因方面取得了更多进展，而且在确定基因与环境暴露之间的协同作用方面也取得了更多进展。基因-环境相互作用的检测很重要，因为它可以为临床医生提供一种潜在的干预手段。相互作用的发现很大程度上依赖于强大的统计方法。我们提出了一种检验方法FBAT-I，可用于研究基因-环境相互作用。该检验采用病例-父母三联体设计，并保护统计推断免受由于人群混杂导致的潜在虚假结果的影响。
