Sakaguchi Noboru, Rao Theertham P, Nakata Katsuyasu, Nanbu Hironobu, Juneja Lekh R
Nutritional Foods Division, Taiyo Kagaku Co. Ltd., 9-5 Akahori-Shinmachi, Yokkaichi, Mie 510-0825, Japan.
Int J Vitam Nutr Res. 2004 Jan;74(1):3-9. doi: 10.1024/0300-9831.74.1.3.
Unlike commercial ferric pyrophosphate, micronized dispersible ferric pyrophosphate (MDFP: Sun-Active Fe) does not precipitate and is completely dispersible in liquid form. MDFP shows a sharp particle size distribution at a nanometer level, which is several times smaller than that of commercial ferric pyrophosphate. The bioavailability of MDFP was compared to ferric pyrophosphate, sodium ferrous citrate, and ferrous sulfate by three bioavailability tests in rats; namely the serum iron concentration curve, the hemoglobin regeneration efficiency, and Association of Official Analytical Chemists' hemoglobin repletion test. The high area under curve value, a lag in peak time, and continued high serum iron concentration by MDFP over the other iron compounds indicates a sustained release of iron in the serum iron concentration curve method. MDFP showed the highest hemoglobin regeneration efficiency among all the iron compounds tested. The relative biological value of MDFP per unit of ferrous sulfate in each bioavailability test showed a high value as compared to other iron compounds. The above results suggest that MDFP is an ideal compound with high bioavailability for iron fortification in various liquid applications.
与市售焦磷酸铁不同，微粉化可分散焦磷酸铁（MDFP：Sun-Active Fe）不会沉淀，并且能以液体形式完全分散。MDFP在纳米级别呈现出尖锐的粒径分布，比市售焦磷酸铁的粒径小几倍。通过在大鼠身上进行的三项生物利用度试验，将MDFP的生物利用度与焦磷酸铁、柠檬酸亚铁钠和硫酸亚铁进行了比较；即血清铁浓度曲线、血红蛋白再生效率以及美国官方分析化学家协会的血红蛋白补充试验。在血清铁浓度曲线法中，MDFP的曲线下面积值高、峰值时间滞后且血清铁浓度持续高于其他铁化合物，表明铁在持续释放。在所有测试的铁化合物中，MDFP的血红蛋白再生效率最高。在每项生物利用度试验中，MDFP相对于硫酸亚铁每单位的相对生物值与其他铁化合物相比都具有较高的值。上述结果表明，MDFP是一种在各种液体应用中具有高生物利用度的理想铁强化化合物。
